Nitric Oxide Donors:  Chemical Activities and Biological Applications

Wang, Peng George; Xian, Ming; Tang, Xiaoping; Wu, Xue‐Jun; Zhang, Wen; Cai, Tingwei; Jañczuk, Adam

doi:10.1021/cr000040l

Cited by 1,254 publications

(1,113 citation statements)

References 633 publications

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“…[16][17][18] The nanoparticles spontaneously release tunable levels of NO under aqueous conditions at physiological temperature and pH, and thus represent attractive vehicles for delivering NO. Nanoparticle delivery of NO has two main advantages over previously-developed small molecule NO donor systems (e.g., diazeniumdiolates, nitrosothiols, and metal-NO complexes 19,20 ). First, the rate of NO release is easily modulated as a function of nanoparticle size, composition, and/or surface hydrophobicity, thereby allowing for control over the duration of NO release.…”

mentioning

confidence: 99%

Bactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles

Hetrick

Shin²,

Stasko³

et al. 2008

ACS Nano

322

380

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The utility of nitric oxide (NO)-releasing silica nanoparticles as a novel antibacterial is demonstrated against Pseudomonas aeruginosa. Nitric oxide-releasing nanoparticles were prepared via co-condensation of tetraalkoxysilane with aminoalkoxysilane modified with diazeniumdiolate NO donors, allowing for the storage of large NO payloads. Comparison of the bactericidal efficacy of the NO-releasing nanoparticles to 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), a small molecule NO donor, demonstrated enhanced bactericidal efficacy of nanoparticle-derived NO and reduced cytotoxicity to healthy cells (mammalian fibroblasts). Confocal microscopy revealed that fluorescently-labeled NO-releasing nanoparticles associated with the bacteria, providing rationale for the enhanced bactericidal efficacy of the nanoparticles. Intracellular NO concentrations were measurable when the NO was delivered from nanoparticles as opposed to PROLI/NO. Collectively, these results demonstrate the advantage of delivering NO via nanoparticles for antimicrobial applications.Keywords nitric oxide; silica nanoparticle; antibacterial; bactericidal; cytotoxicity; reactive nitrogen species; reactive oxygen species Antibiotic resistance has resulted in bacterial infections becoming the most common cause of infectious disease-related death. 1,2 In the United States alone, nearly 2 million people per year acquire infections during a hospital stay, of which approximately 90,000 die. 2 The primary culprits behind such deadly infections are antibiotic-resistant pathogens, which are responsible for approximately 70% of all lethal nosocomial infections. The growing danger of life-threatening infections and the rising economic burden of resistant bacteria have created a demand for new antibacterial therapeutics.The use of nanoparticles as delivery vehicles for bactericidal agents represents a new paradigm in the design of antibacterial therapeutics. To date, most antibacterial nanoparticles have been engineered using traditional antibiotics that are either incorporated within the particle scaffold or attached to the exterior of the particle. In many cases, such particles have exhibited greater efficacy than their constituent antibiotics alone. For example, Gu et al. reported that vancomycin-capped gold nanoparticles exhibited a 64-fold improvement in efficacy over vancomycin alone. 3 Similarly, silver nanoparticles have schoenfisch@unc.edu. Supporting Information Available: Synthesis of FITC-modified silica nanoparticles, AFM analysis of nanoparticle dimensions, scavenging of NO by TSB, and confocal fluorescence microscopy images of PROLI/NO-treated P. aeruginosa cells. This material is available free of charge via the Internet at http://pubs.acs.org. NIH Public AccessAuthor Manuscript ACS Nano. Author manuscript; available in PMC 2013 February 13. shown greater antibacterial activity than silver ion (Ag + ) in solution due to the direct toxicity of the particles and tunable release of Ag + based on nanocomposite size. [4][...

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mentioning

confidence: 99%

Bactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles

Hetrick

Shin²,

Stasko³

et al. 2008

ACS Nano

322

380

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“…There are several reports that NO has positive effects on plants (Beligni and Lamattina 1999;Hung et al 2002;Guo et al 2003). SNP used as an NO donor in the experiments; if it degrades to cyanide group it will inactivate the terminal oxidase/cytochrome c oxidase of the respiratory chain (Wang et al 2002). It will regulate transfer of electron to oxygen by alternative oxidase and will cause the loss of energy in the form of heat.…”

Section: Resultsmentioning

confidence: 99%

Positive effects of nitric oxide onSolanum lycopersicum

Singh

Yadav

Amist

2012

Journal of Plant Interactions

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The present work examines benzoic acid (BA) induced stress in Solanum lycopersicum and explores the possible mechanism through which sodium nitroprusside (SNP) protects plants. Tomato seeds were soaked for 3 h in 250 mM SNP and 0.5, 1.0, and 1.5 mM BA with and without SNP. Seeds soaked in distilled water were treated as control. Seed germination (SG) and radicle length (RL) were recorded in Petri plate culture. SG and RL inhibition was concentration dependent in BA. SNP enhanced SG and RL. Twenty-one-days old seedlings were grown in hydroponic culture in Hoagland solution and BA at 0.5, 1.0, and 1.5 mM with and without SNP. The morphological and biochemical parameters of seedlings were assayed. Average growth rate of root and shoot, dry weight, sugar, pigment and protein content, and activity of nitrate reductase decreased in seedlings treated with BA while increased in SNP with and without BA. Lipid peroxidation increased in seedlings treated with BA but decreased in BA 'SNP. SNP protected the seedlings against BA induced oxidative stress by scavenging reactive oxygen species. SNP demonstrated a positive role against BA toxicity which was evident from increased activities of antioxidant enzymes.

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“…The NO-releasing assay was determined by Griess test (Wang et al, 2002), and NO kit (Cat. A012) was purchased from Nanjing Jiancheng Bioengineering Institute.…”

Section: The No-releasing Assaymentioning

confidence: 99%

“…In this work, tamibarotene was used as a basic model drug to be coupled with furoxans, which are NO donors that display remarkable antitumor activities (Wang et al, 2002;Cerecetto et al, 2005;Huerta et al, 2008;Hirst et al, 2010), to synthesize a new compound named QT-011. QT-011 was proposed to exert synergistic effects at multiple target sites and significantly enhance efficacy by releasing NO and tamibarotene through in vivo metabolism.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Antitumor Activity of a Tamibarotene-Furoxan Derivative

Wang¹,

Duan²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Multi-target drug design, in which drugs are designed as single molecules to simultaneously modulate multiple physiological targets, is an important strategy in the field of drug discovery. QT-011, a tamibarotene-furoxan derivative, was here prepared and proposed to exert synergistic effects on antileukemia by releasing nitric oxide and tamibarotene. Compared with tamibarotene itself, QT-011 displayed stronger antiproliferative effects on U937 and HL-60 cells and was more effective evaluated in a nude mice U937 xenograft model in vivo. In addition, QT-011 could release nitric oxide which might contribute to the antiproliferative activity. Autodocking assays showed that QT-011 fits well with the hydrophobic pocket of retinoic acid receptors. Taken together, these results suggest that QT-011 might be a highly effective derivative of tamibarotene and a potential candidate compound as antileukemia agent.

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Nitric Oxide Donors: Chemical Activities and Biological Applications

Cited by 1,254 publications

References 633 publications

Bactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles

Bactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles

Positive effects of nitric oxide onSolanum lycopersicum

Preparation and Antitumor Activity of a Tamibarotene-Furoxan Derivative

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