Nitric oxide donors offer protection to RBC from storage lesion

Sengupta, Prattusha; Mahalakshmi, Vijayaraghavan; Stebin, Justus Jijo; Ganesh, Subhadra; Suganya, Natarajan; Chatterjee, Suvro

doi:10.1016/j.tracli.2020.07.002

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Moreover, pre-treatment of RBCs with NO-donors seems to guarantee better RBC storage quality, reducing the amount of hemolysis (measured as LDH activity) and the depletion of vital metabolites (such as 2,3-diphosphoglycerate) [ 174 ]. Similar results were obtained with RBC pre-transfusion treatment with gaseous NO or NO-donors [ 175 ].…”

Section: Introductionmentioning

confidence: 99%

Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

Signori

Magliocca

Hayashida

et al. 2022

ICMx

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Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of organ dysfunction, respectively. In this narrative review, we aimed at elucidating the mechanisms behind the role of NO in the respiratory and cardio-cerebrovascular systems, in the presence of a healthy or dysfunctional endothelium. NO is a key player in maintaining multiorgan viability with adequate organ blood perfusion. We report on its physiological endogenous production and effects in the circulation and within the lungs, as well as the pathophysiological implication of its disturbances related to NO depletion and excess. The review covers from preclinical information about endogenous NO produced by nitric oxide synthase (NOS) to the potential therapeutic role of exogenous NO (inhaled nitric oxide, iNO). Moreover, the importance of NO in several clinical conditions in critically ill patients such as hypoxemia, pulmonary hypertension, hemolysis, cerebrovascular events and ischemia–reperfusion syndrome is evaluated in preclinical and clinical settings. Accordingly, the mechanism behind the beneficial iNO treatment in hypoxemia and pulmonary hypertension is investigated. Furthermore, investigating the pathophysiology of brain injury, cardiopulmonary bypass, and red blood cell and artificial hemoglobin transfusion provides a focus on the potential role of NO as a protective molecule in multiorgan dysfunction. Finally, the preclinical toxicology of iNO and the antimicrobial role of NO—including its recent investigation on its role against the Sars-CoV2 infection during the COVID-19 pandemic—are described.

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Section: Introductionmentioning

confidence: 99%

Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

Signori

Magliocca

Hayashida

et al. 2022

ICMx

View full text Add to dashboard Cite

show abstract

The development and application of a novel reagent for fixing red blood cells with glutaraldehyde and paraformaldehyde

Wang³

et al. 2023

Hematology

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Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction

Meegan

Bastarache

Ware

2021

American Journal of Physiology-Lung Cellular and Molecular Phys

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Levels of circulating cell-free hemoglobin are elevated during hemolytic and inflammatory diseases and contribute to organ dysfunction and severity of illness. Though several studies have investigated the contribution of hemoglobin to tissue injury, the precise signaling mechanisms of hemoglobin-mediated endothelial dysfunction in the lung and other organs are not yet completely understood. The purpose of this review is to highlight the knowledge gained thus far and the need for further investigation regarding hemoglobin-mediated endothelial inflammation and injury in order to develop novel therapeutic strategies targeting the damaging effects of cell-free hemoglobin.

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Nitric oxide donors offer protection to RBC from storage lesion

Cited by 4 publications

References 36 publications

Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

The development and application of a novel reagent for fixing red blood cells with glutaraldehyde and paraformaldehyde

Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction

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