Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates

Locascio, Annamaria; Annona, Giovanni; Caccavale, Filomena; D’Aniello, Salvatore; Agnisola, Claudio; Palumbo, Anna

doi:10.3390/ijms241311182

Cited by 7 publications

(6 citation statements)

References 178 publications

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“…Interestingly, HNO exhibits potent antioxidant activity and may contribute to cellular antioxidant defense. This suggests that the interaction between H 2 S and NO may represent an additional mechanism through which H 2 S exerts its antioxidant effects [ 80 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of H2S and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of H2S, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating H2S’s roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of H2S in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of H2S in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness H2S’s potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize H2S’s pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.

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Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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“…These enzymes have been identified in inflammatory cell infiltrates 36 . Under physiological conditions, NO plays a number of positive roles by relaxing vascular and bronchial smooth muscles, inhibiting platelet aggregation, participating in neurotransmission and immune processes 37 – 39 . In turn, excess NO exerts proinflammatory effects and can contribute to bronchial hyperreactivity and pulmonary endothelial damage, which has been observed in COVID-19 patients 40 , 41 .…”

Section: Discussionmentioning

confidence: 99%

“…Cytokines decrease the availability of endogenous NO, prostaglandin and its analogs, which leads to endothelial dysfunction and damage 44 . In addition, increased production of proinflammatory markers and prothrombotic factors increases the risk of serious chronic complications not only in the respiratory tract, but also in vascular and nervous systems 37 , 45 . In the present study, NO levels were higher in COVID-19 patients than in the control group and convalescents, and they tended to increase with the severity of disease symptoms.…”

Section: Discussionmentioning

confidence: 99%

Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19

Wolszczak-Biedrzycka,

Dorf,

Matowicka-Karna

et al. 2024

Sci Rep

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Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, the aim of this study was to assess selected nitrosative stress parameters and protein glycoxidation products in COVID-19 patients and convalescents relative to healthy subjects, including in reference to the severity of COVID-19 symptoms. The diagnostic utility of nitrosative stress and protein glycoxidation biomarkers was also evaluated in COVID-19 patients. The study involved 218 patients with COVID-19, 69 convalescents, and 48 healthy subjects. Nitrosative stress parameters (NO, S-nitrosothiols, nitrotyrosine) and protein glycoxidation products (tryptophan, kynurenine, N-formylkynurenine, dityrosine, AGEs) were measured in the blood plasma or serum with the use of colorimetric/fluorometric methods. The levels of NO (p = 0.0480), S-nitrosothiols (p = 0.0004), nitrotyrosine (p = 0.0175), kynurenine (p < 0.0001), N-formylkynurenine (p < 0.0001), dityrosine (p < 0.0001), and AGEs (p < 0.0001) were significantly higher, whereas tryptophan fluorescence was significantly (p < 0.0001) lower in COVID-19 patients than in the control group. Significant differences in the analyzed parameters were observed in different stages of COVID-19. In turn, the concentrations of kynurenine (p < 0.0001), N-formylkynurenine (p < 0.0001), dityrosine (p < 0.0001), and AGEs (p < 0.0001) were significantly higher, whereas tryptophan levels were significantly (p < 0.0001) lower in convalescents than in healthy controls. The ROC analysis revealed that protein glycoxidation products can be useful for diagnosing infections with the SARS-CoV-2 virus because they differentiate COVID-19 patients (KN: sensitivity—91.20%, specificity—92.00%; NFK: sensitivity—92.37%, specificity—92.00%; AGEs: sensitivity—99,02%, specificity—100%) and convalescents (KN: sensitivity—82.22%, specificity—84.00%; NFK: sensitivity—82,86%, specificity—86,00%; DT: sensitivity—100%, specificity—100%; AGE: sensitivity—100%, specificity—100%) from healthy subjects with high sensitivity and specificity. Nitrosative stress and protein glycoxidation are intensified both during and after an infection with the SARS-CoV-2 virus. The levels of redox biomarkers fluctuate in different stages of the disease. Circulating biomarkers of nitrosative stress/protein glycoxidation have potential diagnostic utility in both COVID-19 patients and convalescents.

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“…Nitric oxide (NO) serves as a pivotal signaling molecule in nearly all organisms, playing a central role in signaling pathways associated with various physiological and pathological processes [ 68 ]. Another function of nitric oxide is that it acts as an antioxidant, especially to lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Impact of rising temperature on physiological and biochemical alterations that affect the viability of blood cells in American bullfrog crossbreeds

Chaiyasing,

Jinagool,

Wipassa

et al. 2024

Heliyon

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Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates

Cited by 7 publications

References 178 publications

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19

Impact of rising temperature on physiological and biochemical alterations that affect the viability of blood cells in American bullfrog crossbreeds

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