Nitric oxide generated by the compound RuBPY promotes the vascular smooth cell membrane hyperpolarization

Pereira, Amanda C.; Lunardi, Claure N.; Paulo, Michele; Silva, Roberto Santana da; Bendhack, Lusiane Maria

doi:10.1016/j.ejps.2013.01.003

Cited by 13 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The NO level peaks in the beginning, with subsequent rapid decrease in its concentration within the following 200 s [35]. Addition of a specific fluorescence probe for NO, DAF-2DA, to the aortic slices exposed to SNP, reveals significantly increased fluorescence intensity (∆FI: 49.4% ± 4.0%; n = 5) [36]. The system takes 195 s to reach maximum rat aorta relaxation [35,36,37].…”

Section: Sodium Nitroprusside and Its Effects On Vascular Tone Andmentioning

confidence: 99%

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Lima

Silva

et al. 2014

Molecules

View full text Add to dashboard Cite

Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects.

show abstract

Section: Sodium Nitroprusside and Its Effects On Vascular Tone Andmentioning

confidence: 99%

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Lima

Silva

et al. 2014

Molecules

View full text Add to dashboard Cite

show abstract

“…Since CO and NO induce vasorelaxation, these CO‐ and NO‐releasing ruthenium complexes were tested for their vasorelaxing effect. Many of them indeed elicit vasorelaxation, which is then attributed to the release of CO or NO [8–11]. However, in a recent study using the ruthenium‐containing CO‐releasing molecule [RuCl 2 (CO) 3 ] 2 (=CORM‐2), we found that its vasorelaxing effect could not completely be explained by CO release as CORM‐2 showed a stronger relaxation than CO as such.…”

Section: Introductionmentioning

confidence: 75%

The influence of ruthenium on vascular tone

Pauwels

Boydens

Voorde

2015

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Furthermore, it was demonstrated that the complex RuBPY requires metabolization to elicit vasorelaxation. It was suggested that the nitrite group of RuBPY is converted into radicalar NO which appears to be catalysed by the sGC enzyme . RuBPY does not only activate sGC, but also induces hyperpolarization of the cell membrane and subsequent vasodilation which is blocked by tetraethylammonium as well as a by high KCl concentration …”

Section: Ruthenium‐based No‐donating Moleculesmentioning

confidence: 99%

Ruthenium-based nitric oxide-donating and carbon monoxide-donating molecules

Pauwels

Boydens

Daele

et al. 2016

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives Over the past few years, the use of metallocomplexes for medical purposes has considerably grown. Because of its favourable characteristics, ruthenium has taken a significant place in this expanding field of research. Several ruthenium-containing metal compounds have been developed as delivery agents of physiological important molecules such as nitric oxide (NO) and carbon monoxide (CO). Key findings This review focuses on the (vaso)relaxant capacity of rutheniumbased NO-donating and CO-donating molecules in view of their potential usefulness in the treatment of cardiovascular diseases and erectile dysfunction. Summary Ruthenium seems to be a valuable candidate for the design of NOdonating and CO-donating molecules. To date, ruthenium remains of interest in drug research as the search for new alternatives is still necessary.

show abstract

Nitric oxide generated by the compound RuBPY promotes the vascular smooth cell membrane hyperpolarization

Cited by 13 publications

References 33 publications

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

The influence of ruthenium on vascular tone

Ruthenium-based nitric oxide-donating and carbon monoxide-donating molecules

Contact Info

Product

Resources

About