Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis

Du, J.; Li, Manli; Kong, Dongdong; Wang, Lei; Lv, Qiang; Wang, Jinzheng; Bao, Fang; Gong, Qingqiu; Xia, Jinchan; He, Yulong

doi:10.1093/jxb/ert429

Cited by 35 publications

(22 citation statements)

References 66 publications

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“…Recently, EIN3 was shown to repress miR164 transcription by binding to its promoter, thereby up-regulating transcript levels of ORE1, leading to early senescence . Thus, ethylene is an important trigger of ORE1 gene expression, as reported earlier (He et al, 2005b;Du et al, 2014).…”

Section: Discussionsupporting

confidence: 71%

Transcription Factor ATAF1 in Arabidopsis Promotes Senescence by Direct Regulation of Key Chloroplast Maintenance and Senescence Transcriptional Cascades

et al. 2015

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ORCID IDs: 0000-0001-6523-6848 (S.M.-B.); 0000-0002-5789-4071 (S.B.).Senescence represents a fundamental process of late leaf development. Transcription factors (TFs) play an important role for expression reprogramming during senescence; however, the gene regulatory networks through which they exert their functions, and their physiological integration, are still largely unknown. Here, we identify the Arabidopsis (Arabidopsis thaliana) abscisic acid (ABA)-and hydrogen peroxide-activated TF Arabidopsis thaliana ACTIVATING FACTOR1 (ATAF1) as a novel upstream regulator of senescence. ATAF1 executes its physiological role by affecting both key chloroplast maintenance and senescence-promoting TFs, namely GOLDEN2-LIKE1 (GLK1) and ORESARA1 (ARABIDOPSIS NAC092), respectively. Notably, while ATAF1 activates ORESARA1, it represses GLK1 expression by directly binding to their promoters, thereby generating a transcriptional output that shifts the physiological balance toward the progression of senescence. We furthermore demonstrate a key role of ATAF1 for ABA-and hydrogen peroxide-induced senescence, in accordance with a direct regulatory effect on ABA homeostasis genes, including NINE-CIS-EPOXYCAROTENOID DIOXYGENASE3 involved in ABA biosynthesis and ABC TRANSPORTER G FAMILY MEMBER40, encoding an ABA transport protein. Thus, ATAF1 serves as a core transcriptional activator of senescence by coupling stress-related signaling with photosynthesis-and senescence-related transcriptional cascades.

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Section: Discussionsupporting

confidence: 71%

Transcription Factor ATAF1 in Arabidopsis Promotes Senescence by Direct Regulation of Key Chloroplast Maintenance and Senescence Transcriptional Cascades

et al. 2015

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“…These results suggest that the crosstalk between NO and sugars may be complex and that several other processes are involved or affected. For example, NO affects auxin transport (Fernández‐Marcos, Sanz, Lewis, Muday, & Lorenzo ), cytokinin signalling (Feng et al ; Liu et al ), ethylene signalling (Du et al ), gibberellin signalling, and light signalling (Bai et al ), which may influence sugar metabolism indirectly.…”

Section: Resultsmentioning

confidence: 99%

Nitric oxide induces monosaccharide accumulation through enzyme S‐nitrosylation

Zhang

Luo

Zhang

et al. 2017

Plant Cell & Environment

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Nitric oxide (NO) is extensively involved in various growth processes and stress responses in plants; however, the regulatory mechanism of NO-modulated cellular sugar metabolism is still largely unknown. Here, we report that NO significantly inhibited monosaccharide catabolism by modulating sugar metabolic enzymes through S-nitrosylation (mainly by oxidizing dihydrolipoamide, a cofactor of pyruvate dehydrogenase). These S-nitrosylation modifications led to a decrease in cellular glycolysis enzymes and ATP synthase activities as well as declines in the content of acetyl coenzyme A, ATP, ADP-glucose and UDP-glucose, which eventually caused polysaccharide-biosynthesis inhibition and monosaccharide accumulation. Plant developmental defects that were caused by high levels of NO included delayed flowering time, retarded root growth and reduced starch granule formation. These phenotypic defects could be mediated by sucrose supplementation, suggesting an essential role of NO-sugar cross-talks in plant growth and development. Our findings suggest that molecular manipulations could be used to improve fruit and vegetable sweetness.

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“…In plants, NO regulates developmental transitions such as seed germination1, photomorphogenesis23, flowering45), fruit ripening6 and leaf senescence78. NO is also a key regulatory molecule in the response of plants to environmental stress910.…”

mentioning

confidence: 99%

Nitric oxide triggers a transient metabolic reprogramming in Arabidopsis

León

Costa

Castillo

2016

Sci Rep

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Nitric oxide (NO) regulates plant growth and development as well as responses to stress that enhanced its endogenous production. Arabidopsis plants exposed to a pulse of exogenous NO gas were used for untargeted global metabolomic analyses thus allowing the identification of metabolic processes affected by NO. At early time points after treatment, NO scavenged superoxide anion and induced the nitration and the S-nitrosylation of proteins. These events preceded an extensive though transient metabolic reprogramming at 6 h after NO treatment, which included enhanced levels of polyamines, lipid catabolism and accumulation of phospholipids, chlorophyll breakdown, protein and nucleic acid turnover and increased content of sugars. Accordingly, lipid-related structures such as root cell membranes and leaf cuticle altered their permeability upon NO treatment. Besides, NO-treated plants displayed degradation of starch granules, which is consistent with the increased sugar content observed in the metabolomic survey. The metabolic profile was restored to baseline levels at 24 h post-treatment, thus pointing up the plasticity of plant metabolism in response to nitroxidative stress conditions.

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Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis

Abstract: SummaryThe NES1/MAD1 gene acts antagonistically with the EIN2-associated ORE1 signalling pathway to modulate the nitric oxide-induced Arabidopsis cotyledon senescence

Cited by 35 publications

References 66 publications

Transcription Factor ATAF1 in Arabidopsis Promotes Senescence by Direct Regulation of Key Chloroplast Maintenance and Senescence Transcriptional Cascades

Transcription Factor ATAF1 in Arabidopsis Promotes Senescence by Direct Regulation of Key Chloroplast Maintenance and Senescence Transcriptional Cascades

Nitric oxide induces monosaccharide accumulation through enzyme S‐nitrosylation

Nitric oxide triggers a transient metabolic reprogramming in Arabidopsis

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