Nitric Oxide Inhibitory Carbazole Alkaloids from the Folk Medicine <i>Murraya tetramera</i> C.C. Huang

Lyu, Haining; Ren, Wen Xiu; Tu, Peng‐Fei; Jiang, Yong

doi:10.1002/cbdv.202000490

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Microphyltrine, microphyldines A-O and microphyldine P were isolated from the stem and leaves of M. microphylla [41]. Nitric oxide production induced by LPS in BV-2 microglial cells was inhibited by phyto-carbazole alkaloids from M. tetramera and M. kwangsiensis [19,42], with IC 50 values ranging from 5.1 to 15.1 µM [43].…”

Section: Phyto-carbazole Alkaloids From the Genus Murrayamentioning

confidence: 99%

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Tan

Sharma

2022

Antioxidants

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Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera Murraya, Clausena, Glycosmis, Micromelum and Zanthoxylum). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs.

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Section: Phyto-carbazole Alkaloids From the Genus Murrayamentioning

confidence: 99%

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Tan

Sharma

2022

Antioxidants

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“…With the application and development of detection technology, the effective components with medicinal value have been gradually isolated and identified. In vitro activity studies have shown that the flavonoids and alkaloids of M. tetramera have significant inhibitory effects on many cancer cells [12,13], as well as anti-inflammatory and analgesic effects [14,15]and anthelmintic effects [16]. Alkaloids are intermediates of plant nitrogen metabolism derived from different amino acids.…”

Section: Introductionmentioning

confidence: 99%

Integrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang

Zhou,

Xing,

et al. 2024

BMC Plant Biol

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Background Murraya tetramera Huang is a traditional Chinese woody medicine. Its leaves contain flavonoids, alkaloids, and other active compounds, which have anti-inflammatory and analgesic effects, as well as hypoglycemic and lipid-lowering effects, and anti-tumor effects. There are significant differences in the content of flavonoids and alkaloids in leaves during different growth cycles, but the synthesis mechanism is still unclear. Results In April 2021, new leaves (one month old) and old leaves (one and a half years old) of M. tetramera were used as experimental materials to systematically analyze the changes in differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) with transcriptomics and metabolomics technology. This was done to identify the signaling pathways of flavonoid and alkaloid synthesis. The results showed that the contents of total alkaloids and flavonoids in old leaves were significantly higher than those in new leaves. Thirteen flavonoid compounds, three isoflavone compounds, and nineteen alkaloid compounds were identified, and 125 and 48 DEGs related to flavonoid and alkaloid synthesis were found, respectively. By constructing the KEGG (Kyoto Encyclopedia of Genes and Genomes) network of DEGs and DAMs, it was shown that the molecular mechanism of flavonoid biosynthesis in M. tetramera mainly focuses on the “flavonoid biosynthetic pathway” and the “flavonoid and flavonol biosynthetic pathway”. Among them, p-Coumaryl alcohol, Sinapyl alcohol, Phloretin, and Isoquercitrin were significantly accumulated in old leaves, the up-regulated expression of CCR (cinnamoyl-CoA reductase) might promote the accumulation of p-Coumaryl alcohol, upregulation of F5H (ferulate-5-hydroxylase) might promote Sinapyl alcohol accumulation. Alkaloids, including indole alkaloids, pyridine alkaloids, imidazole alkaloids, and quinoline alkaloids, were significantly accumulated in old leaves, and a total of 29 genes were associated with these substances. Conclusions These data are helpful to better understand the biosynthesis of flavonoids and alkaloids in M. tetramera and provide a scientific basis for the development of medicinal components in M. tetramera.

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“…[15,16]. M. tetramera contains various flavonoids, coumarins, alkaloids, and sesquiterpenes [17][18][19][20]. Some of the isolated compounds have exhibited significant cytotoxic effects [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Flavonoids from the Leaves and Twigs of Murraya tetramera

You

Zhang

et al. 2021

Molecules

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Cytotoxic flavonoids of Murraya tetramera were investigated in this study. A novel flavonoid and twelve known flavonoids, including seven flavones (1–7), three flavanones (8–10), and three chalcones (11–13) were isolated from the leaves and twigs of Murraya tetramera. Chemical structures were elucidated by NMR combined with MS spectral analysis, and the new compound (6) was confirmed as 3’,5’-dihydroxy-5,6,7,4’-tetramethoxyflavone. Furthermore, all the isolated flavonoids were evaluated for their cytotoxicities against murine melanoma cells (B16), and human breast cancer cells (MDA-MB-231) by CCK-8 assay. Among them, compounds 7, 13, and 5 exhibited potent cytotoxic activities against B16 cell lines (IC50 = 3.87, 7.00 and 8.66 μg/mL, respectively). Compounds 5, 13, and 12 displayed potent cytotoxicities against MDA-MB-231 cell lines (IC50 = 3.80, 5.95 and 7.89 μg/mL, respectively). According to the correlation of the structure and activity analysis, 5-hydroxyl and 8-methoxyl substituents of the flavone, 8-methoxyl substituent of the flavanone, and 3’,5’-methoxyl substituents of the chalcone could be critical factors of the high cytotoxicity. The results indicated that the active flavonoids have potential to be developed as leading compounds for treating cancers.

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Nitric Oxide Inhibitory Carbazole Alkaloids from the Folk Medicine Murraya tetramera C.C. Huang

Cited by 3 publications

References 35 publications

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Integrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang

Cytotoxic Flavonoids from the Leaves and Twigs of Murraya tetramera

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