Nitric oxide may underlie learned fear in the elevated T-maze

Calixto, A.V.; Vandresen, N; Nucci, Gilberto De; Moreno, Heitor; Faria, Moacir Serralvo

doi:10.1016/s0361-9230(01)00480-4

Cited by 27 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, a biologically inactive isomer D-NAME showed no such effect. These results are consistent with previous studies using L-NAME (Calixto et al, 2001;Kopf et al, 2001). In a previous study (see Telegedy & Kokavszky, 1997), it has been reported that i.c.v.…”

Section: Discussionsupporting

confidence: 93%

“…Some detailed experiments must be carried out using this learning paradigm. The present study possesses the same differences when compared to other studies using Nω-Nitro-L-Arginine Methyl Ester Hydrochloride and L-arginine in drug dose, administration time, and the assessment of either behavioral parameters in conjunction with the latency for avoidance (Calixto et al, 2001;Kopf et al, 2001).…”

mentioning

confidence: 64%

“…Some studies reported that nitric oxide synthase inhibitors do not alter passive avoidance learning (Böhme et al, 1993;Toyoda et al, 1996;Yamada et al, 1996;Telegdy & Kokavszky, 1997), whereas others found that they inhibit the retention of passive avoidance behavior (Hölscher & Rose 1992;Qiang et al, 1997;Rickard et al, 1998;Kopf et al, 2001;Calixto et al, 2001). These data currently seem inadequate to reveal the nitric oxide in passive avoidance learning.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of Nitric Oxide on Passive Avoidance Learning in Rats

Yıldırım

Marangoz

2004

International Journal of Neuroscience

View full text Add to dashboard Cite

To investigate the effects of nitric oxide (NO) on passive avoidance learning, L-NAME, D-NAME, and L-arginine were administered i.p. 30 min prior to learning trial; the effects of these substances were tested 24 h later using a passive avoidance apparatus in rats. To reveal the effect of NO on consolidation of acquired memory, L-NAME, D-NAME, and L-arginine were administered i.p. immediately after learning trials and animals were tested 24 h later. Effect of NO on retention was also investigated by injecting L-NAME, D-NAME, and L-arginine (same dosages) 30 min prior to 24 h testing (retrieval). L-NAME administered 30 min before and 24 h after learning trial significantly decreased the avoidance latency but there was no significant effect on consolidation. L-Arginine appeared to enhance the retention of acquired memory significantly, whereas D-NAME had no effect on any testing regime. The results suggest that NO may be involved in learning and retention of passive avoidance.

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 64%

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Nitric Oxide on Passive Avoidance Learning in Rats

Yıldırım

Marangoz

2004

International Journal of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Rat De Oliveira and Guimarães (1999) EPM MB (10-100 nmol) dlPAG Rat Ferreira et al (1999) EPM 7-NI, (6 mg/kg i.p., or 20 nmol intra-hippocampus) SNAP, (20 or 40 nmol) 8-cGMP (40 nmol Podhorna and Brown (2000) Ultrasonic vocalization L-NAME, (20 mg/kg), L-arginine, (100 mg/kg), NMDA (1-5 mg/kg) i.p. Rat Pokk et al (2001) EPM, staircase 7-NIO (20-120 mg/kg) i.p Mouse Calixto et al (2001) ETM L-NAME (5-50 mg/kg) i.p. Rat Pokk and Vali (2002) EPMC stress a 7-NIO (20-120 mg/kg) i.p.…”

Section: Role Of No In Other Brain Areas Related To Defensive Reactionsmentioning

confidence: 99%

Role of nitric oxide in brain regions related to defensive reactions

Guimarães

Beijamini

Moreira

et al. 2005

Neuroscience & Biobehavioral Reviews

119

View full text Add to dashboard Cite

“…First, NOS inhibitors administration before acquisition or at the early, but not at late stages of memory consolidation, impairs the memory of various tasks in rodents (Estall et al 1993;Ohno et al 1993;Bernabeu et al 1995;Fin et al 1995;Huang and Lee 1995;Yamada et al 1995;Baratti and Kopf 1996;Zou et al 1998;Kopf et al 2001;Calixto et al 2001;da Cunha et al 2005). Second, the cognitive impairment induced by NOS inhibitors is prevented by the injection of L-arginine, the NOS substrate, at doses that have no effect on memory per se (Ohno et al 1993;Huang and Lee 1995;Baratti and Kopf 1996;Kopf et al 2001;da Cunha et al 2005) or by NO donors (Meyer et al 1998).…”

Section: Introductionmentioning

confidence: 99%