Nitric oxide mediates anti‐inflammatory action of extracorporeal shock waves

Abstract

Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon-c (IFN-c) plus tumour necrosis factor-a (TNF-a). Finally, ESW treatment efficiently downregulates NF-jB activation and NF-jB-dependent gene expression, including inducible NOS and TNF-a. The present report suggests a possible molecular mechanism of the anti-inflammatory action of ESW treatment.

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

“…Finally we are evaluating whether a modification in skin thickness is detectable by ultrasonography in a longer period of observation. patients is in accordance with literature [6,7,17], but further studies are needed.…”

“…During the last 10 years this tecnique was found to induce an immediate anthalgic and anti-inflammatory effect and a long-term tissue regeneration together with increase of angiogenesis [5][6][7][8][9]16]. One of the possible mechanisms of action of the anti-inflammatory effect of ESWT may be related to the ability of ESW to keep local NO contents at a physiological level in the early phase of inflammatory response, enhancing either a non-enzymatic or enzymatic production of NO [15].…”

“…One of the possible mechanisms of action of the anti-inflammatory effect of ESWT may be related to the ability of ESW to keep local NO contents at a physiological level in the early phase of inflammatory response, enhancing either a non-enzymatic or enzymatic production of NO [15]. Therefore induction of NO 9 synthesis has been suggested to be one of the most important mechanism implicated in the anti-inflammatory effect of ESWT, while increased expression of VEGF and the consequent mobilization of endothelial progenitor cells can explain the proangiogenic action [6][7][8]17]. It has been recently demonstrated that, in addition to angiogenesis due to migration and proliferation of endothelial cells in situ, EPCs contribute to neovascularization in ischemic tissue through a vasculogenetic mechanism and through secretion of a variety of angiogenic factors [18][19].…”

“…First applied in 1980 for the treatment of kidney stones, during the last 10 years this tecnique was found to induce an immediate anthalgic and antiinflammatory effect and a long-term tissue regeneration together with increase of angiogenesis [5][6][7][8][9].…”

Impacts of Shock Wave Versus Ankle Orthosis on Spastic Calf Muscles in Hemiparetic Children

“…Little information is available about the use of shock wave therapy on spastic muscle. Improvements detected in the study group using shock wave therapy may be attributed to non-enzymatic [22] and enzymatic nitric oxide (NO) synthesis [23,24] . NO is involved in neuromuscular junction formation in the peripheral nervous system [25] and in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity [26] .…”