Nitric Oxide Mediates Inhibitory Effect of Interleukin‐1β on Estrogen Production in Human Granulosa‐Luteal Cells

Tobai, H.; Nishiya, I

doi:10.1111/j.1447-0756.2001.tb01216.x

Cited by 24 publications

(14 citation statements)

References 30 publications

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“…In cultured human granulosa cells, IL-1β inhibited estradiol production and accelerated progesterone degradation [34,45]. Within the follicle of AL hens there is an increase in IL-1β protein and a decline in granulosa progesterone production and follicle wall MMP activities despite increased leukocyte infiltration.…”

Section: Discussionmentioning

confidence: 95%

Feed Intake Alters Immune Cell Functions and Ovarian Infiltration in Broiler Hens: Implications for Reproductive Performance1

Liu

Xie

Chang

et al. 2014

Biology of Reproduction

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Leukocytes are known to participate in ovarian activities in several species, but there is a surprising lack of information for the common chicken. Broiler hens consuming feed ad libitum (AL) exhibit a number of ovarian irregularities, but leukocyte functions are unstudied. In contrast to feed-restricted (R) hens, AL feeding for 7 wk significantly reduced egg production and clutch length while increasing pause length and atretic follicle numbers (P < 0.05). Granulosa cells from F1 follicles of AL hens contained less progesterone, and follicle walls were thicker with loose fibrous morphology and had less collagenase-3-like gelatinolytic activity but more IL-1beta (P < 0.05) production, suggestive of slower maturation in ovulatory process and inflamed necrosis. Interestingly, while highly infiltrated with immune cells, particularly heterophils, IL-1beta, MMP-22-like, and gelatinase A activities were reduced in AL hen peripheral heterophils and monocytes (P < 0.05); however, AL monocytes showed an increase in phagocytosis rate (P < 0.05). Generation of reactive oxygen intermediates was also suppressed in AL heterophils but increased in AL monocytes (P < 0.05). In contrast to leukocyte-free control, both AL and R heterophils and monocytes suppressed progesterone production and increased cell death in a dose-dependent manner when coincubated with granulosa cells at different ratios (P < 0.05). AL monocytes suppressed progesterone production more, but AL heterophils were less proapoptotic when compared to their R counterparts (P < 0.05). Alterations of cellular ceramide content (P < 0.05) corresponded to the discrepancy between heterophil and monocyte functionality. In conclusion, leukocyte dysfunction contributes to impaired ovarian activities of overfed broiler hens.

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Section: Discussionmentioning

confidence: 95%

Feed Intake Alters Immune Cell Functions and Ovarian Infiltration in Broiler Hens: Implications for Reproductive Performance1

Liu

Xie

Chang

et al. 2014

Biology of Reproduction

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“…Furthermore, IL-1 may have some effect on estradiol-17 production. It has been shown in vitro in human granulosa cells that IL-1 inhibits estradiol-17 production (Barak et al 1992), most probably by increasing NO production (Tobai & Nishiya 2001). IL-1 could also inhibit P450 aromatase activity (Yasuda et al 1990, Ghersevich et al 2001 as well as other enzymes involved in estradiol-17 synthesis (Hurwitz et al 1991, Ghersevich et al 2001.…”

Section: No Productionmentioning

confidence: 99%

The interleukin-1 system and female reproduction

Gérard¹,

Caillaud²,

Martoriati³

et al. 2004

Journal of Endocrinology

148

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Interleukins (ILs) are known best for their involvement in the immune system and their role during inflammation. In the ovary, a growing body of evidence suggests that the ovarian follicle is a site of inflammatory reactions. Thus ovarian cells could represent sources and targets of ILs. Since then, the IL-1 system components (IL-1 , IL-1 , IL-1 receptor antagonist, IL-1 receptors) have been demonstrated to have several sites of synthesis in the ovary. These factors have been localized in the various ovarian cell types, such as the oocyte, granulosa and theca cells, in several mammalian species. IL-1-like bioactivity has been reported in human and porcine follicular fluid at the time of ovulation. The role of IL-1 in local processes is still poorly known, although there is evidence for involvement in the ovulation process, and in oocyte maturation. More precisely, IL-1 may be involved in several ovulationassociated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production. IL-1 also regulates ovarian steroidogenesis. These different aspects of the involvement of the IL-1 system in important aspects of female reproduction are discussed.

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“…However, in preterm birth, an increase in the levels of PGE2 in maternal serum and amniotic fluid has been documented in pregnant women with preterm birth 15 . Previous studies have demonstrated that in the inflammation state, expression of iNOS mRNA and NO production were also increased and secondary NO had pathophysiological affects 16–19 . Under pathophysiological conditions, high concentrations of NO can be either beneficial (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effect of lipopolysaccharide on the production of prostaglandin E2 and inhibition of uterine contractions by nitric oxide in pregnant inducible nitric oxide synthase knockout mice

Takahashi

Okawa

Asano

et al. 2012

J of Obstet and Gynaecol

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Nitric Oxide Mediates Inhibitory Effect of Interleukin‐1β on Estrogen Production in Human Granulosa‐Luteal Cells

Abstract: IL-1beta stimulated NO production, and NO inhibited the production of estradiol.

Cited by 24 publications

References 30 publications

Feed Intake Alters Immune Cell Functions and Ovarian Infiltration in Broiler Hens: Implications for Reproductive Performance1

Feed Intake Alters Immune Cell Functions and Ovarian Infiltration in Broiler Hens: Implications for Reproductive Performance1

The interleukin-1 system and female reproduction

Effect of lipopolysaccharide on the production of prostaglandin E2 and inhibition of uterine contractions by nitric oxide in pregnant inducible nitric oxide synthase knockout mice

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