Nitric oxide metabolite changes in gentamicin-induced nephrotoxicity; the effects of antioxidant vitamins

Abstract

In this experimental study, 68 adult Wistar rats made the subject of the study. Administration of vitamin E and C, in an individual manner, can have some more favorable effects on urea, creatinine and nitrite level in GM nephrotoxicity than their coadministration. On the other hand, there is a gender difference, in response to vitamin E and C in which male gender responded more favorably to the antioxidant vitamins.

Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

“…The same results were obtained when we evaluated the effects of both CAR and DIC on the nitrite level of rats and we found that DIC could elevate the level of nitrite in rats. This finding was in total agreement with the previous results disclosed that NO plays a vital role in DIC-induced damage [ 42 , 43 ]. Moreover, we found that CAR could remarkably diminish the levels of NO in DIC-treated rats, shedding another light on the anti-oxidant property of the agent.…”

Silymarin mitigates diclofenac-induced liver toxicity through inhibition of inflammation and oxidative stress in male rats

“…Increase in level of nitrite in DIC-only treated rats indicated the effect of NO in liver toxicity induced by DIC. Our results are in line with the prior studies that have shown NO creates important role in chemical toxicity (32,33). Remarkable reduction of nitrite content in silymarin treated groups suggested that this antioxidant offered liver protection in DIC exposed rats by reduce the NO content and nitrosative stress.…”

Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress

“…In this vein, previous investigations also suggested that DIC engages NO for exerting its devastating effects on the organs. 34,38 Notable diminutions of nitrite level in DIC plus QR treated group implied that this agent exerted renal protection in DIC exposed animals through the diminution of NO levels and nitrosative stress.…”