Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder

Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders

“…Moreover, studies showed that patients with recurrent depression had significantly elevated levels of NO in serum (Dimopoulos et al 2008). However, Talarowska et al did not detect any significant differences in the expression of inducible nitric oxide synthase between patients with a single depression episode and a group suffering from the recurrent form of the disease (Talarowska et al 2012).…”

Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin.

“…[3] and decreased [4], potentially due to differing NO subtypes, different states, or different treatments received. In particular, MDD patients that attempt suicide are reported to have high plasma NO levels [5].…”

Cognitive psychotherapy treatment decreases peripheral oxidative stress parameters associated with major depression disorder

“…In addition, inhibitors of nitric oxide synthase are known to enhance the extracellular levels of serotonin and dopamine in major brain areas involved in the pathophysiology of depression (Wegener, Volke & Rosenberg, 2000). Clinical studies show an increased production of systemic NO in depressed patients, suggesting their involvement with depressive symptoms (Herken et al, 2007;Talarowska et al, 2012).…”

“…The test is based on the reduction of nitrate to nitrite using the granulated cadmium and conversion, using Greiss reagent, of nitrite into a purple compoundchromophore, which is measured colorimetrically at 540 nm (Talarowska et al, 2012).…”