Nitric oxide reduces organ injury and enhances regeneration of reduced-size livers by increasing hepatic arterial flow

Abstract

Nitric oxide improves the postoperative course of rats with reduced-size livers by modulating hepatic macrohaemodynamics and mediating regeneration and cytoprotection, but not by reducing hepatic hyperperfusion and the accompanying sinusoidal shear stress.

A critical appraisal of the hemodynamic signal driving liver regeneration

“…Administration of NO donors or prostaglandin analogues also provides a potential option for patients whose liver have to regenerate. In rats with 85% PH substitution of NO has been shown to enhance hepatic arterial inflow which cause greater increase in cell proliferation, with thus an improvement of liver function [12]. However, pharmacological reduction of portal pressure by somatostatin leading to attenuation of shear stress in small-for-size livers was accompanied by a better liver function [130].…”

“…Previous findings indicate that NO is involved in the priming of hepatocytes as it may switch hepatocytes into a growth factor-responsive state through the down-regulation of Sadenosylmethionine levels [41]. Accordingly, several studies have illustrated that liver regeneration is inhibited by administration of the NOS antagonist NG-nitro-L-arginine methyl ester [12,106,124] and restored by application of NO donors [12,103,104,125]. Observations of impaired liver regeneration and hepatocyte survival in iNOS- [96] and eNOS-knockout mice [77] provide additional proof for the importance of NO-mediated signaling in liver regeneration.…”

Reduced Hepatic Arterial Perfusion Impairs the Recovery From Focal Hepatic Venous Outflow Obstruction in Liver-Resected Rats

“…Nitric oxide (NO) has been demonstrated to improve the postoperative course of rats with reduced-size livers by modulating hepatic macrohemodynamics and mediating regeneration (9). Here, we raised the hypothesis that the imbalance between portal venous and hepatic arterial inflow in liver-resected rats subsequently aggravates the liver damage and delays the recovery process after FHVOO.…”

Effects of lycopene on oxidative stress and remnant liver histology after partial hepatectomy in rats

“…It has also been reported that NO treatment supports liver regeneration, improves liver function and has hepatoprotective effects (31,32). NO can mediate a number of physiological and pathological reactions (33).…”

“…NO could initiate production of reactive oxygen species after partial hepatectomy and during liver regeneration. Cantré et al (31) had reported that inhibition of the release of NO decreased liver damage. We observed increased NO levels with increased lipid peroxidation levels.…”