Nitric oxide regulates synaptic transmission between spiny projection neurons

Sagi, Yotam; Heiman, Myriam; Peterson, Jayms D.; Musatov, Sergei; Scarduzio, Mariangela; Logan, Stephen M.; Kaplitt, Michael G.; Surmeier, D. James; Greengard, Paul

doi:10.1073/pnas.1420162111

Cited by 25 publications

(21 citation statements)

References 30 publications

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“…Taverna et al found that collateral connectivity was profoundly reduced in two mouse models of PD [62], in agreement with work by Flores-Barrera et al [20]. This may result, at least in part, from impaired NO signaling in parkinsonian animals [52]. However, a recent report did not find any significant change in collateral transmission in a genetic model of PD [64].…”

Section: Introductionsupporting

confidence: 69%

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Striatal synapses, circuits, and Parkinson's disease

Zhai

Tanimura

Graves

et al. 2018

Current Opinion in Neurobiology

147

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The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson’s disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.

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Section: Introductionsupporting

confidence: 69%

“…In PD models, both up-regulation and down-regulation of the NO/cGMP signaling pathway have been reported [50–52]. Why there is a discrepancy is unclear.…”

Section: Introductionmentioning

confidence: 99%

Striatal synapses, circuits, and Parkinson's disease

Zhai

Tanimura

Graves

et al. 2018

Current Opinion in Neurobiology

147

View full text Add to dashboard Cite

show abstract

“…For this mechanism to work, the signaling mechanisms governing LTP induction would have to oppose those of NO-LTD. As Ca 2+ entry through NMDA receptors is necessary for LTP induction in SPNs (Shen et al, 2008), phosphodiesterase 1 – a striatally enriched, Ca 2+ /calmodulin dependent phosphodiesterase that preferentially degrades cGMP – might mediate this interaction (Bender, 2006). An additional possibility may be that NO released from PLTSIs also simultaneously tunes GABAergic inputs within the striatum, specifically from other interneurons onto SPNs, a possibility that has been described elsewhere (Nugent et al, 2007; Sagi et al, 2014). …”

Section: Discussionmentioning

confidence: 95%

Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses

et al. 2015

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SUMMARY Experience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential to goal-directed behavior and habit formation. One major form of striatal plasticity – long-term depression (LTD) – has long appeared to be expressed only pre-synaptically. Contrary to this view, nitric oxide (NO) generated by striatal interneurons was found to induce a post-synaptically expressed form of LTD at SPN glutamatergic synapses. This form of LTD was dependent on signaling through guanylyl cyclase and protein kinase G – both of which are abundantly expressed by SPNs. NO-LTD was unaffected by local synaptic activity or by antagonism of endocannabinoid (eCb) and dopamine receptors; all of which modulate canonical, pre-synaptic LTD. Moreover, NO signaling disrupted induction of this canonical LTD by inhibiting dendritic Ca2+ channels regulating eCb synthesis. These results establish an interneuron-dependent, heterosynaptic form of post-synaptic LTD that could act to promote stability of the striatal network during learning.

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“…For instance, GABA can be closely related to the NO-cGMP pathway in that NMDAR and NOS can modulate hippocampal GABAergic inhibition via NO-cGMP signaling (Gasulla and Calvo, 2015). Furthermore, the activation of GABA also inhibits the NO-cGMP signaling pathway (Sagi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ketamine Produces Anesthesia and Analgesia in Miniature Pigs Via NO-cGMP Signaling Pathway

Liu¹

2019

PVJ

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Ketamine is a commonly used anesthetic for injection in pigs. However, how ketamine produces anesthesia and analgesia is unclear. Twenty Bama miniature pigs were randomly divided into four groups: saline control, induction (T1=15 min), deep anesthesia (T2=45 min) and recovery (T3=75 min). The cerebrum cortex, cerebellum, brainstem, hippocampus, and thalamus were collected. Results indicated that the activities or content of the indicators in different regions was inhibited by ketamine at different periods. The Na + -K + -ATPase activity in the cerebral cortex, hippocampus, thalamus and brainstem decreased by 48.69, 20.27, 51.18 and 36.44%, respectively, while the Ca 2+ -Mg 2+ -ATPase activity in each region decreased by 28. 75, 28.59, 46.58, 64.11 and 34.68%, respectively. The NOS activity in regions except thalamus decreased by 49.76, 13.12, 13.77 and 15.96%, respectively. respectively. The content of No in the cerebral cortex, cerebellum, hippocampus and thalamus decreased by 33.25, 46.93, 44.44 and 50.00%, respectively, and the cGMP content in the cerebral cortex, cerebellum and hippocampus decreased by 28.25, 29.87 and 40.60%, respectively. The changes of each index were consistent with the physiological responses of pigs when they are anesthetized. In summary, ketamine is suitable for pig anesthesia. It produces anesthetic and analgesic effects via the NO-cGMP signaling pathway, however, more drugs need to be studied for an effective balanced anesthetic protocol that meets demands.

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Nitric oxide regulates synaptic transmission between spiny projection neurons

Cited by 25 publications

References 30 publications

Striatal synapses, circuits, and Parkinson's disease

Striatal synapses, circuits, and Parkinson's disease

Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses

Ketamine Produces Anesthesia and Analgesia in Miniature Pigs Via NO-cGMP Signaling Pathway

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