Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Abstract

Traditional phototherapies face the issue that the insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces the feasibility of cancer therapy. Here, an implantable nitric oxide (NO)‐release device is developed to achieve long‐term, long‐distance, remote‐controllable gas therapy for cancer. The device consists of a wirelessly powered light‐emitting diode (wLED) and S‐nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining the NO‐release wLED (NO‐wLED). It is found that NO release from the NO‐wLED can be triggered by wireless charging and the concentration of produced NO reaches 0.43 × 10−6 m min−1, which can achieve a killing effect on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect on the growth of orthotopic cancer when the implanted NO‐wLED is irradiated by wireless charging. In addition, recurrence of cancer can be prevented by NO produced from the NO‐wLED after surgery. By illumination in the body, this strategy overcomes the poor penetration and long‐wavelength dependence of traditional phototherapies, which also provides a promising approach for in vivo gas therapy remote‐controlled by wireless charging.

Controllable Nitric Oxide‐Delivering Platforms for Biomedical Applications

“…In our view, quicker and nimbler "switches" should be exploited. For example, electrically controlled NO release has been reported by Zhang et al [170] and Anikeeva et al [171] The last but not least, more in-depth studies on the therapeutic mechanism of NO in various diseases are necessary. A deeper understanding of the physiological and pathological functions of NO is the bedrock guiding the design and exploitation of NO-delivery platforms.…”

Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective

“…Zhang et al. [ 132 ] also developed an implantable nitric oxide (NO) release device (NO‐wLED) to achieve long‐term, long‐distance, remotely controlled gas therapy against cancer. The device consists of a wireless light‐emitting diode (wLED) and S‐nitrosoglutathione wrapped with polydimethylsiloxane.…”

“…The FDRD can be modified into wearable medical devices for patient-controlled drug release. Zhang et al [132] Figure 7. a) Wireless metronomic device for tumor PDT. Reproduced with permission.…”

Synergistic Therapy Using Doxorubicin-Loading and Nitric Oxide-Generating Hollow Prussian Blue Nanoparticles with Photoacoustic Imaging Potential Against Breast Cancer

“…The pro-drug nitroglycerin and sodium nitroprusside (SNP) are the most widely used NO-releasing small molecules. Several NO-releasing moieties have been proposed, such as organic nitrates/nitrites, 10,12 S-nitroglutathione (GSNO), 19,29,31 S-nitrosothiols (SNO), 14,32,35 Roussin's black salt, 25,28,33 N-diazeniumdiolate (NONOate), 20 L-arginine (L-Arg) 26,34 and S-nitroso-N-acetylpenicillamine (SNAP). 11 However, the short half-life in blood and poor enrichment in tumors restrict their potential use in vivo.…”