Nitric Oxide-Releasing Hydrophobic Polymers: Preparation, Characterization, and Potential Biomedical Applications

Reynolds, Melissa M.; Frost, Megan C.; Meyerhoff, Mark E.

doi:10.1016/j.freeradbiomed.2004.06.019

Cited by 105 publications

(90 citation statements)

References 35 publications

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“…Reviews by Reynolds, Frost, and Meyerhoff [7,8] detail approaches that have been used to impart NO-release properties to hydrophobic polymer systems. Keefer [9] reviews the application of NO-release materials in clinical medicine.…”

Section: Introductionmentioning

confidence: 99%

S-Nitroso-N-acetyl-D-penicillamine covalently linked to polydimethylsiloxane (SNAP–PDMS) for use as a controlled photoinitiated nitric oxide release polymer

Gierke

Nielsen

Frost

2011

Science and Technology of Advanced Materials

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Nitric oxide (NO) plays a critical role in the regulation of a wide variety of physiological processes. It is a potent inhibitor of platelet adhesion and aggregation, inhibits bacterial adhesion and proliferation, is implicated in mediating the inflammatory response toward implanted devices, plays a role in tumor growth and proliferation, and is a neurotransmitter. Herein, we describe the synthesis and NO-release properties of a modified polydimethylsiloxane that contains S-nitroso-N-acetyl-D-penicillamine covalently attached to the cross-linking agent (SNAP-DMS). Light from a C503B-BAN-CY0C0461 light-emitting diode (470 nm) was used as an external trigger to allow precise control over level and duration of NO release ranging from a surface flux of zero to approximately 3.5 × 10 −10 mol cm −2 min −1 . SNAP-PDMS films stored in the dark released NO after 297 days, indicating the long-term stability of SNAP-PDMS.

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Section: Introductionmentioning

confidence: 99%

S-Nitroso-N-acetyl-D-penicillamine covalently linked to polydimethylsiloxane (SNAP–PDMS) for use as a controlled photoinitiated nitric oxide release polymer

Gierke

Nielsen

Frost

2011

Science and Technology of Advanced Materials

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“…NO release can be modulated by changing the amount of particle blended or changing the physicochemical properties of polymers (e.g., molecular weight and structure). [81] In addition, for derivatized NO-releasing particles, the risk of by-product leaching from NO donor decomposition can be eliminated as they are covalently modified and physically entrapped in the polymer matrix. [82] However, more attention on toxicity is suggested when introducing particles for NO delivery, especially when nanoscale materials are applied.…”

Section: No-releasing Particle-based Scaffoldsmentioning

confidence: 99%

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

et al. 2017

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Nitric oxide (NO) acts a pivotal role in regulating various physiological processes of vasodilation, platelet aggregation, and vascular smooth muscle cell mitogenesis and proliferation. This makes NO a promising candidate for the treatment of cardiovascular problems like hypertension and vascular stenosis. However, the high reactivity of NO poses an issue for effective NO delivery. To overcome this limitation, recent developments on three-dimensional (3D) materials have been explored with either physical or chemical incorporation of NO releasing donors, to provide spatiotemporal control over NO-signaling pathways in blood vessels. Here, we offer an overview on the current efforts, and propose future perspectives for precise regulation on NO delivery in advanced 3D materials toward proper vascular functionality.

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“…60 New materials are being developed that rely on S-nitrosothiols and/or nitrates that are already circulating in blood. Gappa-Fahlenkamp et al 61 immobilized L-cysteine on Dacron and polyurethane surfaces.…”

Section: Kapadia Et Al Modified Prosthetic Vascular Conduits 1879mentioning

confidence: 99%

Modified Prosthetic Vascular Conduits

Popowich²,

2008

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Abstract-Atherosclerosis in the form of peripheral arterial disease results in significant morbidity. Surgical treatment options for peripheral arterial disease include angioplasty, endarterectomy, and bypass grafting. For bypass grafting, vein remains the conduit of choice; however, poor quality and limited availability have led to the use of prosthetic materials. Unfortunately, because of a lack of endothelium and compliance mismatch, neointimal hyperplasia develops aggressively, resulting in high failure rates. To improve graft patency, investigators have developed surgical, chemical, and biological graft modifications. This review describes common prosthetic materials, as well as approaches currently in use and under investigation to modify and improve prosthetic conduits for bypass grafting in an effort to improve graft patency rates. (Circulation. 2008;117:1873-1882.)

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Nitric Oxide-Releasing Hydrophobic Polymers: Preparation, Characterization, and Potential Biomedical Applications

Cited by 105 publications

References 35 publications

S-Nitroso-N-acetyl-D-penicillamine covalently linked to polydimethylsiloxane (SNAP–PDMS) for use as a controlled photoinitiated nitric oxide release polymer

S-Nitroso-N-acetyl-D-penicillamine covalently linked to polydimethylsiloxane (SNAP–PDMS) for use as a controlled photoinitiated nitric oxide release polymer

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

Modified Prosthetic Vascular Conduits

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