Nitric Oxide–Releasing Nanoparticles Accelerate Wound Healing by Promoting Fibroblast Migration and Collagen Deposition

Han, George; Nguyen, Long N.; Macherla, Chitralekha; Chi, Yuling; Friedman, Joel M.; Nosanchuk, Joshua D.; Martinez, Luis R.

doi:10.1016/j.ajpath.2011.12.013

Cited by 180 publications

(130 citation statements)

References 32 publications

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“…Thus, Nitric Oxide associated with nanoparticles has been shown to be an important product for wound healing in several aspects. As observed in study A8, it increases the speed of healing and the recruitment of angiogenic factors (23) . In another study, A9, the benefits of epithelization acceleration and its bactericidal capacity were evaluated.…”

Section: Discussionmentioning

confidence: 52%

“…The increase in healing speed was also analyzed in study A8, in which a nitric oxide nanoparticle (NO-NP) dressing was used. When this product was applied in in vitro to human fibroblasts and in in vivo rats, increased collagen deposition during wound healing, rapid progression of wound closure, and improved angiogenesis rates was observed (23) . The combined data suggest that NO-NP improves wound healing, facilitates cell migration and collagen deposition.…”

Section: Discussionmentioning

confidence: 99%

“…The NLS/CsA-loaded bioadhesive gel formulation significantly increased the rate of mucosal repair. (23) Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition…”

Section: A6mentioning

confidence: 99%

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Utilização de nanopartículas no tratamento de feridas: revisão sistemática

Silva

Aguiar

Rodrigues

et al. 2018

Rev. esc. enferm. USP

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Objective:To analyze the effects of nanoparticle-based dressings on the wound healing process in in vitro animals and human cells based on scientific evidence. Method: A systematic review of the literature in LILACS, PubMed and Science Direct databases. The articles were selected and evaluated for the level of evidence by the application of STROBE. Results: The sample consisted of 12 articles. The application of the products occurred in surgical wounds, burns, infected wounds and gingival ulcers in laboratory animals, as well as in vitro tests, demonstrating that among other advantages, the nanoparticle-based dressings increased the healing speed, had good antibacterial capacity and were non cytotoxic agents. Conclusion: Based on the analyzed articles, it can be affirmed that dressings containing nanocomposites are quite promising and are shown as a great therapeutic option in wound healing.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Utilização de nanopartículas no tratamento de feridas: revisão sistemática

Silva

Aguiar

Rodrigues

et al. 2018

Rev. esc. enferm. USP

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show abstract

“…However, it should additionally be considered that a rat exhibits higher hepatobiliary excretion of gadolinium-based contrast media than a human (gadobenate dimeglumine: > 30 %, gadoxetate disodium: > 70 % biliary excretion) [34,35]. Under physiological conditions, fibroblasts play a special role in scarring and wound healing [36]. Fibroblast activity is triggered by numerous non-specific events occurring within the context of injury and trauma to tissue.…”

Section: Lesion Developmentmentioning

confidence: 99%

Application of Extracellular Gadolinium-based MRI Contrast Agents and the Risk of Nephrogenic Systemic Fibrosis

Heverhagen

Krombach

Gizewski

2014

Fortschr Röntgenstr

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!Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of gadolinium-containing contrast media which have reduced the number of new cases of NSF to almost zero. However, it is for precisely this reason that the greatest care must still be taken to ensure that these guidelines are complied with. The most important factors are renal function, the quantity of gadolinium administered and coexisting diseases such as inflammation. All of these factors crucially influence the quantity of gadolinium released from the chelat in the body. This free gadolinium is thought to be the trigger for NSF. Other important factors are the stability of the gadolinium complex and furthermore the route of its elimination from the body. Partial elimination via the liver might be an additional protective mechanism. In conclusion, despite the NSF risk, contrast-enhanced MRI is a safe diagnostic procedure which can be used reliably and safely even in patients with severe renal failure, and does not necessarily have to be replaced by other methods.

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“…109,110 During remodeling, NO predominantly regulates the collagen synthesis in fibroblasts as treatment with NO donors (e.g., dietary l-arginine or iNOS overexpression) significantly enhanced the collagen deposition in the wound. [111][112][113] Over the past two decades, NO delivery devices/vehicles have been developed to transit the therapeutic potential of NO in chronic wounds. It is extremely difficult to handle NO as a gas molecule owing to its instability and its oxidation potential to the toxic nitrogen dioxide molecule.…”

Section: 81mentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

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Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

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Nitric Oxide–Releasing Nanoparticles Accelerate Wound Healing by Promoting Fibroblast Migration and Collagen Deposition

Cited by 180 publications

References 32 publications

Utilização de nanopartículas no tratamento de feridas: revisão sistemática

Utilização de nanopartículas no tratamento de feridas: revisão sistemática

Application of Extracellular Gadolinium-based MRI Contrast Agents and the Risk of Nephrogenic Systemic Fibrosis

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

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