Nitric Oxide Releasing Polymeric Coatings for the Prevention of Biofilm Formation

Fleming, George; Aveyard, Jenny; Fothergill, Joanne L.; McBride, Fiona; Raval, Rasmita; D’Sa, Raechelle A.

doi:10.3390/polym9110601

Cited by 34 publications

(30 citation statements)

References 62 publications

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“…For obvious reasons, coating cannot be used with food; nevertheless as previously mentioned, food containers and storage boxes can be produced with this technology, preventing adhesion and facilitating disinfection. The results reported in these papers showed higher reduction of adhesion ranging from 1 to 2 Log (CFU/sample) on coating materials . In our study the reduction was limited to 0.5 Log(CFU/sample) when the NO donors were used alone (Fig.…”

Section: Discussionsupporting

confidence: 55%

“…This could be interesting for the production of plastic boxes for food storage. For example, NO‐releasing coatings on (poly(ethylene terephthalate) (PET) and silicone elastomer (SE) has been shown to reduce Pseudomonas aeruginosa adhesion significantly over 24 h, with a reduction measured to be 1 Log (CFU/sample) . Superhydrophobic nitric oxide (NO)‐releasing xerogels supported a reduction in viable P. aeruginosa adhesion by >2 Log (CFU/sample) .…”

Section: Discussionmentioning

confidence: 99%

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Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

et al. 2020

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BACKGROUND Nitric oxide (NO) donors have been used to control biofilm formation. Nitric oxide can be delivered in situ using organic carriers and acts as a signaling molecule. Cells exposed to NO shift from biofilm to the planktonic state and are better exposed to the action of disinfectants. In this study, we investigate the capability of the NO donors molsidomine, MAHAMA NONOate, NO‐aspirin and diethylamine NONOate to act as anti‐adhesion agents on ready‐to‐eat vegetables, as well as dispersants for a number of pathogenic biofilms on plastic. RESULTS Our results showed that 10 pM molsidomine reduced the attachment of Salmonella enterica sv Typhimurium 14 028 to pea shoots and coriander leaves of about 0.5 Log(CFU/leaf) when compared with untreated control. The association of 10 pmol L−1 molsidomine with 0.006% H2O2 showed a synergistic effect, leading to a significant reduction in cell collection on the surface of the vegetable of about 1 Log(CFU/leaf). Similar results were obtained for MAHMA NONOate. We also showed that the association of diethylamine NONOate at 10 mmol L−1 and 10 pmol L−1 with the quaternary ammonium compound diquat bromide improved the effectiveness of biofilm dispersal by 50% when compared with the donor alone. CONCLUSIONS Our findings reveal a dual role of NO compounds in biofilm control. Molsidomine, MAHMA NONOate, and diethylamine NONOate are good candidates for either preventing biofilm formation or dispersing biofilm, especially when used in conjunction with disinfectants. Nitric oxide compounds have the potential to be developed into a toolkit for pro‐active practices for good agricultural practices (GAPs), hazard analysis and critical control points (HACCP), and cleaning‐in‐place (CIP) protocols in industrial settings where washing is routinely applied. © 2020 Society of Chemical Industry

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

et al. 2020

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“…NONOate conjugated polymeric materials for antibacterial application: NO releasing hydrogels, reported in [95]; NO releasing nanoparticles, reported in [56,96,97]; NO releasing nanofibers, reported in [98]; NO releasing surface coatings, reported in [99,100,101,102]. …”

Section: Figurementioning

confidence: 99%

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

et al. 2019

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Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era.

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“…75 Moreover, diazeniumdiolate coatings tethered on poly(ethylene terephthalate) and silicone elastomers showed antibacterial efficacy toward Pseudomonas aeruginosa ( P. aeruginosa ) bacteria. 76 Diazeniumdiolate-based acrylonitrile-co-1-vinylimidazole copolymers were reported to be used in sutures. 77 A diazeniumdiolate-based poly(diol citrate) elastomer was also proposed by Ameer group as a coating film for expanded PTFE vascular grafts, 78 in which NO release can only last for 2 days.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a fluorinatedS-nitrosothiol as the nitric oxide donor for fluoropolymer-based biomedical device applications

Zhou

Zhang

et al. 2018

J. Mater. Chem. B

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Fluorinated polymers are widely used as biomaterials in various biomedical implant and device applications. However, thrombogenicity, surface-induced inflammation, and risk of microbial infection remain key issues that can limit their use. In this work, we describe the first nitric oxide (NO) releasing fluorinated polymer, in which a new fluorinated NO donor, S-nitroso-N-pentafluoropropionylpenicillamine (C2F5-SNAP), is incorporated within the polyvinylidene fluoride (PVDF) tubing. The synthesis, decomposition kinetics, and NO-release characteristics of the C2F5-SNAP species are described in detail. Then, using a simple solvent swelling method, we demonstrate that C2F5-SNAP can readily be doped into PVDF tubing. The resulting tubing can release NO for 11 days under physiological conditions, with an NO flux > 0.5 × 10−10 mol/cm2·min over the first 7 days. Due to fluorous-fluorous interactions, the leaching of the fluorinated NO donor and its decomposed products is shown to be very low (less than 5 nmol/mg, total). Further, the new NO-releasing PVDF tubing exhibits significant antimicrobial activity (compared to undoped PVDF tubing) against both gram positive and negative S. aureus and P. aeruginosa bacterial strains over a 7 d test period. This new NO-releasing fluorinated polymer is likely to have the potential to improve the biocompatibility and antimicrobial activity of various biomedical devices.

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Nitric Oxide Releasing Polymeric Coatings for the Prevention of Biofilm Formation

Cited by 34 publications

References 62 publications

Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

Synthesis and characterization of a fluorinatedS-nitrosothiol as the nitric oxide donor for fluoropolymer-based biomedical device applications

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