Nitric oxide‐releasing polyurethane–PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion

Taite, Lakeshia J.; Yang, Perry Pei‐Ju; Jun, Ho−Wook; West, Jennifer L.

doi:10.1002/jbm.b.30850

Cited by 121 publications

(92 citation statements)

References 61 publications

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“…Polyurethanes incorporated with YIGSR selectively promoted EC adhesion and proliferation while minimizing platelet adhesion [40,41]. Glass [42] and PEG hydrogels [43] modified with YIGSR also enhanced EC adhesion and migration.…”

Section: Modifications With Ecm-derived Peptides-cellular Interactionmentioning

confidence: 99%

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Moon¹,

West²

2008

CTMC

206

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Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.

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Section: Modifications With Ecm-derived Peptides-cellular Interactionmentioning

confidence: 99%

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Moon¹,

West²

2008

CTMC

206

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“…Taite and colleagues incorporated this peptide, a diazeniumdiolate nitric oxide (NO) donor, and polyethylene glycol (PEG) into the backbone of polyurethane with the aim to improve the long-term patency of polyurethane vascular grafts (Taite et al, 2008). The modification encouraged the adhesion of ECs to the material.…”

Section: Yigsr Peptidesmentioning

confidence: 99%

Current concepts and new developments for autologous in vivo endothelialisation of biomaterials for intravascular applications

Avci‐Adali

Perle²,

Ziemer³

et al. 2011

eCM

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Circulating endothelial progenitor cells (EPCs) in the peripheral blood of adults represent an auspicious cell source for tissue engineering of an autologous endothelium on blood-contacting implants. Novel materials biofunctionalised with EPC-specific capture molecules represent an intriguing strategy for induction of selective homing of progenitor cells. The trapped EPCs can differentiate into endothelial cells and generate a nonthrombogenic surface on artificial materials. However, the success of this process mainly depends on the use of optimised capture molecules with a high selectivity and affinity. In recent years, various biomedical engineering strategies have emerged for in situ immobilisation of patient's own stem cells on blood contacting materials. The realisation of this in vivo tissue engineering concept and generation of an endothelium on artificial surfaces could exceedingly enhance the performance of not only small calibre vascular grafts and stents, but also, in general all blood-contacting medical devices, such as heart valves, artificial lungs, hearts, kidneys, and ventricular assist devices.

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“…15 NO-releasing material coatings suppress thrombogenic problems in the absence of endothelial cells or in areas that are not fully covered by endothelial cells. 13,14,16 In addition to inhibition of platelet adhesion and activation, 13,14 NO regulates amongst others (a.o.) vascular cell proliferation and migration 17 and the production of vascular endothelial growth factor 18 and/or growth hormone (GH).…”

Section: Introductionmentioning

confidence: 99%

Biomimetic modification of silicone tubes using sodium nitrite–collagen immobilization accelerates endothelialization

et al. 2015

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Biomimetic coatings to increase endothelialization of blood-contacting materials in biomedical devices are promising to improve the biocompatibility of these devices. Although a stable extracellular matrix protein coating on a biomaterial's surface is a prerequisite for endothelial cell attachment, it also stimulates platelet adhesion. Therefore, antithrombotic additives, such as nitric oxide donors, to a stable protein coating might lead to successful endothelialization of a material's surface. We aimed to test whether immobilized bioactive nitrite and acidified nitrite-generating sodium nitrite-collagen conjugate on silicone tubes enhances endothelialization by increasing the number of endothelial cells as well as growth hormone production and by decreasing platelet adhesion. Stable collagen immobilization on acrylic acid-grafted silicone tubes decreased the water contact angle from 102° to 56°. Initial 25 µM sodium nitrite in conjugate resulted in maximal growth hormone production (2.5-fold increase) and endothelial cell number (1.8-fold increase) after 2 days. A 95% confluent endothelial cell monolayer on sodium nitrite-collagen conjugate coating was obtained after 6 days. Maximum (2.7-fold) inhibition of platelet adhesion was reached with initial 500 µM sodium nitrite in conjugate. Our data showing that sodium nitrite-collagen conjugate coating with 25-50 µM sodium nitrite on silicone tubes increases the number of endothelial cells attached and inhibits platelet adhesion suggest that this coating is highly promising for use in blood-contacting parts of biomedical devices. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1311-1321, 2016.

show abstract

Nitric oxide‐releasing polyurethane–PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion

Cited by 121 publications

References 61 publications

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Current concepts and new developments for autologous in vivo endothelialisation of biomaterials for intravascular applications

Biomimetic modification of silicone tubes using sodium nitrite–collagen immobilization accelerates endothelialization

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