Nitric oxide role in anxiety-like behavior, memory and cognitive impairments in animal model of chronic migraine

Taheri, Parichehr; Mohammadi, Fatemeh; Nazeri, Masoud; Zarei, Mohammad; Chamani, Goli; Esfahlani, Mohsen Abedini; Taheri, Farahnaz; Shabani, Mohammad

doi:10.1016/j.heliyon.2020.e05654

Cited by 20 publications

(21 citation statements)

References 46 publications

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“…Beside the orofacial formalin test, used to measure NTG-induced trigeminal hyperalgesia, we adopted the open field test as a tool to evaluate locomotor, exploratory, and anxiety-like behavior in the NTG-based migraine model. Here, we found an alteration of these parameters in the NTG-treated rats, which is in line with previous studies showing the involvement of NO in the modulation of anxiety [59,60] and locomotor activity [61]. Contrary to our results, Sufka and collaborators [62] reported increased locomotor activity 2 h after a single injection of NTG in rats compared to control animals.…”

Section: Discussionsupporting

confidence: 92%

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

Greco¹,

Demartini²,

Francavilla³

et al. 2021

Cells

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The endocannabinoid system exerts an important role in pain processing and modulation. Modulation of the system with hydrolase inhibitors of anandamide (AEA) or 2-arachidonyl glycerol (2-AG) has proved effective in reducing migraine-like features in animal models of migraine. Here, we investigated the effect of dual inhibition of the AEA and 2-AG catabolic pathways in the nitroglycerin-based animal model of migraine. The dual inhibitor JZL195 was administered to rats 2 h after nitroglycerin or vehicle injection. Rats were then exposed to the open field test and the orofacial formalin test. At the end of the tests, they were sacrificed to evaluate calcitonin gene-related peptide (CGRP) serum levels and gene expression of CGRP and cytokines in the cervical spinal cord and the trigeminal ganglion. The dual inhibitor significantly reduced the nitroglycerin-induced trigeminal hyperalgesia and pain-associated behavior, possibly via cannabinoid 1 receptors-mediated action, but it did not change the hypomotility and the anxiety behaviors induced by nitroglycerin. The decreased hyperalgesia was associated with a reduction in CGRP and cytokine gene expression levels in central and peripheral structures and reduced CGRP serum levels. These data suggest an antinociceptive synergy of the endocannabinoid action in peripheral and central sites, confirming that this system participates in reduction of cephalic pain signals.

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Section: Discussionsupporting

confidence: 92%

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

Greco¹,

Demartini²,

Francavilla³

et al. 2021

Cells

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“…After exposure to repeated stress, mice stayed longer in the peripheral zone than the control mice ( Kaufmann and Brennan, 2018 ; Hwang et al, 2020 ), which is a behavior parameter widely used for assessing anxiety ( Seibenhener and Wooten, 2015 ). Additionally, in the migraine-like model induced by nitroglycerin, authors verified increased anxiety-like symptoms in the open field test in rats ( Taheri et al, 2020 ). Our study also presented other aspects related to migraine-like pain, such as anxiety-like symptoms and a decrease in exploratory behavior, which are relevant aspects of a model of migraine ( Kaufmann and Brennan, 2018 ; Avona et al, 2020a ; Hwang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 89%

“…Migraine is also associated with psychiatric disorders, such as anxiety ( Karimi et al, 2021 ). Some previous studies indicate that nociception in migraine-like models could be accompanied by exploratory behavior alteration and anxiety-like symptoms ( Araya et al, 2020 ; Taheri et al, 2020 ). In this respect, we also detected that stress induction decreased the time of different exploratory behaviors, such as rearing and sniffing, and the number of crossings.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, using a migraine model induced by nitroglycerin i. p. injection, a sexual dimorphic effect was detected, in which females had higher nociception than males ( Alarcón-Alarc ón et al, 2021 ). However, most of the studies using models of migraine have not evaluated sexual differences, and male mice or rats are normally tested ( Khasar et al, 2009 ; Taheri et al, 2020 ). Previous studies utilizing sound stress have demonstrated hind paw nociception but have only performed the nociceptive tests in male rats ( Crettaz et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

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Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

et al. 2022

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Migraine represents one of the major causes of disability worldwide and is more prevalent in women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently reported trigger in migraine patients, but the underlying mechanisms are not fully understood. However, it is known that patients with migraine have higher levels of plasma inflammatory cytokines and calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable sound is already used as a model of painful sensitization, but migraine-like behaviors and sexual dimorphism have not yet been evaluated. This study characterized nociception and anxiety-related symptoms after the induction of sound stress in mice. C57BL/6 mice (20–30 g) were exposed to unpredictable sound stress for 3 days, nonconsecutive days. We observed enhanced plasma corticosterone levels on day 1 after stress induction. First, 7 days after the last stress session, mice developed hind paw and periorbital mechanical allodynia, grimacing pain behavior, anxiety-like symptoms, and reduced exploratory behavior. The nociceptive and behavioral alterations detected in this model were mostly shown in female stressed mice at day 7 post-stress. In addition, on day 7 post-stress nociception, these behaviors were consistently abolished by the CGRP receptor antagonist olcegepant (BIBN4096BS, 100 mg/kg by intraperitoneal route) in female and male stressed mice. We also demonstrated an increase in interleukine-6 (IL-6), tumor necrosis factor (TNF-α), and CGRP levels in stressed mice plasma, with female mice showing higher levels compared to male mice. This stress paradigm allows further preclinical investigation of mechanisms contributing to migraine-inducing pain.

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“…Chronic nitroglycerin administration in rats led to a decreased percentage of entries and time spent in the open arms of the EPM and reduced time to enter the dark part of the LDB with fewer transitions and decreased time spent in light part of the LDB, all indicating anxiety‐like behavior 164 , 165 (Table 1 ).…”

Section: Cardiovascular Drugs and Anxietymentioning

confidence: 99%

Cardiovascular therapeutics: A new potential for anxiety treatment?

Repova

Aziriova

Krajcirovicova

et al. 2022

Medicinal Research Reviews

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Besides the well-recognized risk factors, novel conditions increasing cardiovascular morbidity and mortality are emerging.Undesirable emotions and behavior such as anxiety and depression, appear to participate in worsening cardiovascular pathologies. On the other hand, deteriorating conditions of the heart and vasculature result in disturbed mental and emotional health. The pathophysiological background of this bidirectional

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Nitric oxide role in anxiety-like behavior, memory and cognitive impairments in animal model of chronic migraine

Cited by 20 publications

References 46 publications

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

Cardiovascular therapeutics: A new potential for anxiety treatment?

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