2001
DOI: 10.1042/0264-6021:3570593
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Nitric oxide synthases: structure, function and inhibition

Abstract: This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family. There is now information on the enzyme structure at all levels from primary (amino acid sequence) to quaternary (dimerization, association with other proteins) structure. The crystal structures of the oxygenase domains of inducible NOS (iNOS) and vascular endothelial NOS (eNOS) allow… Show more

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Cited by 2,387 publications
(1,986 citation statements)
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References 214 publications
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“…9). Therefore, we decided to examine the gene expression levels of a few genes known to be involved in ROS production including NOX1, NOX4 (NADPH oxidases, involved in production of Oxygen radicals 25 ), NOXA1 (NOX-activating protein 26 ) and NOS2 (nitric oxide synthase, involved in the formation of free radicals 27 ).…”
Section: H3r42me 2 -Mediated Gene Repression By Rv1988 During Infectionmentioning
confidence: 99%
“…9). Therefore, we decided to examine the gene expression levels of a few genes known to be involved in ROS production including NOX1, NOX4 (NADPH oxidases, involved in production of Oxygen radicals 25 ), NOXA1 (NOX-activating protein 26 ) and NOS2 (nitric oxide synthase, involved in the formation of free radicals 27 ).…”
Section: H3r42me 2 -Mediated Gene Repression By Rv1988 During Infectionmentioning
confidence: 99%
“…The KCl pre-contracted and cocktail-treated arterial mesenteric vasculatures of control, eNOS or iNOS KO mice were perfused with vehicle or 7-nitroindazole (7-NI) (100 mmol l À1 , for 15 min prior to and during the entire experiments) (Alderton et al, 2001;Ralevic, 2002) to evaluate the implication of neuronal NOS in the reduction in perfusion pressure afforded by PNS. Dose-dependent responses to haCGRP administered as a bolus (in 1 ml) were also assessed in the arterial mesenteric vasculature of control or endothelial NOS knockout mice as well as in 7-NI pretreated vascular circuits derived from wild-type animals.…”
Section: Experimental Protocolsmentioning
confidence: 99%
“…High amounts of NO are produced through the inducible nitric oxide synthase (iNOS) pathway in response to proinflammatory cytokines and bacterial products. Expression of iNOS has been shown to be regulated both at transcriptional and post-translational levels in activated macrophages, but many of the mechanisms are still unknown (MacMicking et al, 1997;Alderton et al, 2001;Kleinert et al, 2003;Aktan, 2004;Korhonen et al, 2005).…”
Section: Introductionmentioning
confidence: 99%