Nitric oxide synthesis inhibition attenuates morphine-induced place preference

Kivastik, Toomas; Rutkauskaite, J.; Zharkovsky, Alexander

doi:10.1016/0091-3057(95)02092-6

Cited by 40 publications

(11 citation statements)

References 17 publications

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“…Moreover, pretreatment with L-NAME suppresses the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine in rats (Pulvirenti et al 1996). In addition, different NOS inhibitors are shown to attenuate place conditioning induced by nicotine, morphine, methamphetamine, alcohol, and cocaine Manzanedo et al 2004;Kivastik et al 1996;Langroudi et al 2005;Li et al 2002;Itzhak and Martin 2000;Kim and Park 1995;Itzhak et al 1998). It was reported that in the alcoholic brain, neuronal NOS protein content is increased in the frontal cortex and the nucleus accumbens brain regions, which were suggested to be involved in the dopaminergic mesolimbic reward system (Gerlach et al 2001).…”

Section: Discussionmentioning

confidence: 98%

“…The NO system is relevant to the rewarding effects of various drugs of abuse. It is suggested that NO may play an important role in nicotine-, morphine-, methamphetamine-, alcohol-, phencyclidine-, and cocaineinduced place preference Manzanedo et al 2004;Kivastik et al 1996;Langroudi et al 2005;Li et al 2002;Itzhak and Martin 2000;Miyamoto et al 2000;Kim and Park 1995;Itzhak et al 1998).…”

Section: Introductionmentioning

confidence: 99%

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Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

et al. 2006

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

et al. 2006

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“…Moreover, the combination of low and per se noneffective doses of morphine and l ‐NAME did not show any effect on place conditioning. Consistently, it has been shown that NOS inhibition could block the place conditioning induced by most effective doses of morphine but it has no effect on per se ineffective doses of morphine [24, 36].…”

Section: Discussionmentioning

confidence: 91%

Melatonin enhances the rewarding properties of morphine: involvement of the nitric oxidergic pathway

Yahyavi-Firouz-Abadi¹,

Tahsili-Fahadan²,

Ghahremani³

et al. 2007

Journal of Pineal Research

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Melatonin has different interactions with opioids including the enhancement of the analgesic effects of morphine and also reversal of tolerance and dependence to morphine. The present study assessed the effect of melatonin on morphine reward in mice using a conditioned place preference (CPP) paradigm. Our data showed that subcutaneous administration of morphine (1-7.5 mg/kg) significantly increased the time spent in the drug-paired compartment in a dose-dependent manner. Intraperitoneal (i.p.) administration of melatonin (1-40 mg/kg) alone did not induce either CPP or conditioned place aversion (CPA), while the combination of melatonin (5-20 mg/kg) and sub-effective dose of morphine (0.5 mg/kg) led to rewarding effect. We further investigated the involvement of the nitric oxidergic pathway in the enhancing effect of melatonin on morphine CPP, by a general nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME). L-NAME (1 and 5 mg/kg, i.p.) alone or in combination with morphine (0.5 mg/kg) did not show any significant CPP or CPA. Co-administration of L-NAME (5 mg/kg) with an ineffective combination of melatonin (1 mg/kg) plus morphine (0.5 mg/kg) produced significant CPP that may imply the similarity of action of melatonin and L-NAME and involvement of the nitric oxidergic pathway in this regard. Our results indicate that pretreatment of animals with melatonin enhances the rewarding properties of morphine via a mechanism which may involve the nitric oxidergic pathway.

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“…L-NA, given intraperitoneally, inhibited morphineinduced place preference in rats, but L-NA by itself showed no reliable effect on place conditioning, suggesting a possible role of NO in the opioid reward process [37]. Intrahippocampal CA1 injections of Larginine increased morphine-induced conditioned place preference in male rats, and this effect was blocked by L-NAME; L-arginine or L-NAME itself did not induce conditioned place preference [38].…”

Section: Conditioned Place Preferencementioning

confidence: 98%

Interactions between morphine and nitric oxide in various organs

Toda¹,

Kishioka

Hatano

et al. 2009

J Anesth

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Nitric oxide (NO) plays obligatory roles as an important intercellular messenger in the control of physiological functions and it also participates in pathophysiological interventions. This labile, gaseous molecule is also involved in mechanisms underlying the beneficial and untoward actions of therapeutic agents. Endogenous NO is formed by endothelial and neurogenic NO synthases that are constitutively present mainly in the endothelium and nervous system, respectively, and is induced by lipopolysaccharides or cytokines mainly in mitochondria, glial cells, and vascular smooth muscle cells. NO modulates the effects of morphine on processes involving the central nervous system, such as learning, memory, convulsion, thermoregulation, and penile erection. This molecule is also involved in the modification of morphine actions on the cardiovascular, digestive, and respiratory systems. Morphine regulates NO bioavailability in various organs. NO formed by inducible NO synthase participates in some morphine actions in the immune system. Information concerning interactions between NO and morphine and other opioids in a variety of organs and tissues is quite useful in establishing new strategies for minimizing the noxious and unintended reactions that are frequently encountered during analgesic therapy.

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Nitric oxide synthesis inhibition attenuates morphine-induced place preference

Cited by 40 publications

References 17 publications

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

Melatonin enhances the rewarding properties of morphine: involvement of the nitric oxidergic pathway

Interactions between morphine and nitric oxide in various organs

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