Nitric oxide, the new architect of epigenetic landscapes

Vasudevan, Divya; Bovee, Rhea C.; Thomas, Douglas D.

doi:10.1016/j.niox.2016.08.002

Cited by 55 publications

(30 citation statements)

References 99 publications

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“…Several studies have described NO-driven epigenetic modifications that control normal biological development and mediate tumorigenesis (Vasudevan et al, 2016). In prostate carcinogenesis, the silencing of glutathione transferase P1-1 ( GSTP1 ) is a common early event that is frequently caused by promoter hypermethylation and correlates with decreased survival.…”

Section: Dichotomous Roles Of No In Cancermentioning

confidence: 99%

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

Keshet

Erez

2018

Disease Models &Amp; Mechanisms

111

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Nitric oxide (NO) is a signaling molecule that plays important roles in diverse biological processes and thus its dysregulation is involved in the pathogenesis of various disorders. In cancer, NO has broad and sometimes dichotomous roles; it is involved in cancer initiation and progression, but also restricts cancer proliferation and invasion, and contributes to the anti-tumor immune response. The importance of NO in a range of cellular processes is exemplified by its tight spatial and dosage control at multiple levels, including via its transcriptional, post-translational and metabolic regulation. In this Review, we focus on the regulation of NO via the synthesis and availability of its precursor, arginine, and discuss the implications of this metabolic regulation for cancer biology and therapy. Despite the established contribution of NO to cancer pathogenesis, the implementation of NO-related cancer therapeutics remains limited, likely due to the challenge of targeting and inducing its protective functions in a cell- and dosage-specific manner. A better understanding of how arginine regulates the production of NO in cancer might thus support the development of anti-cancer drugs that target this key metabolic pathway, and other metabolic pathways involved in NO production.

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Section: Dichotomous Roles Of No In Cancermentioning

confidence: 99%

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

Keshet

Erez

2018

Disease Models &Amp; Mechanisms

111

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“…4). Since then, several studies have described NO-driven epigenetic modifications in a wide range of organisms, which control normal biological development and mediate tumorigenesis [63]. In oral squamous cell carcinoma patients, it is common to find histone hyperacetylation that promotes tumor progression.…”

Section: The Role Of No In Epigeneticsmentioning

confidence: 99%

Nitric Oxide: The Forgotten Child of Tumor Metabolism

2017

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Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients. Exogenous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and triggers angiogenesis. NO regulates posttranslational protein modifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promoting and tumor-suppressing effects. We review mechanisms that link NO to cancer hallmarks, with a perspective of co-targeting NO metabolism with first-line therapies for improved outcome. We highlight the need for quantitative flux analysis to study NO in tumors.

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“…However, due to its nature as a free radical, NO can also produce highly damaging reactive species, such as peroxynitrite, inducing oxidative or nitrosative stress. While the whole gamut of processess where NO is involved are still being elucidated, it has become clear that the interactions of NO in metabolic networks are complex and involve specific aspects, such as NO concentration at the site of action, source (NO synthase, NOS, isoform responsible for its synthesis), site of synthesis, interactions with other reactive species and post-translational modifications (1). …”

Section: Introductionmentioning

confidence: 99%

NO control of mitochondrial function in normal and transformed cells

Tengan¹,

Moraes²

2017

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer.

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Nitric oxide, the new architect of epigenetic landscapes

Cited by 55 publications

References 99 publications

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

Nitric Oxide: The Forgotten Child of Tumor Metabolism

NO control of mitochondrial function in normal and transformed cells

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