Nitrile groups as hydrogen-bond acceptors in a donor-rich hydrogen-bonding network

Acrylamide moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives

“…This additional group forms "nitrile trap" which traps both nucleophilic residues and H-bond donor residues, for nucleophilic residues it undergoes nucleophilic addition at the electrophilic carbon of nitrile whereas for H-bond donor residues it serves as H-bond acceptor via the lone pair on the nitrogen of nitrile group. The advantage of nitrile moiety as a tool for designing various molecules addressing various therapeutic targets was highlighted by many researchers [35][36][37][38][39][40] .…”

A tetra Co(ii/iii) complex with an open cubane Co4O4 core and square-pyramidal Co(ii) and octahedral Co(iii) centres: bifunctional electrocatalytic activity towards water splitting at neutral pH

“…The MeCN N-atoms are somewhat close to the metal coordinated polarized azomethine-CH groups indicating weak intermolecular hydrogen bonding interactions. 21 The C⋯N distance and the C–H⋯N angle are 3.761(17) Å and 153° for the full occupancy MeCN, while they are 4.149(19) Å and 143° for the half occupancy MeCN. The structure of [Co II Co III (μ-OAc)(μ 3 -OH)(μ-L)] 2 is illustrated in Fig.…”

A neutron diffraction study of hydrogen bonding in isostructural potassium and ammonium lanthanoidates

“…We have previously reported the ability of the cdm anion to act as a hydrogen-bond acceptor via the nitrile groups in the structure of (C(NH 2 ) 3 )cdm. 20 This revealed a distinct preference for the nitrile groups to form interactions with near linear CN⋯H angles. Even in instances where there were two donor groups to the same nitrile, it was observed that the bifurcated hydrogen-bonding ring was skewed such that one interaction maintained a near linear geometry.…”