Nitrimines as Reagents for Metal‐Free Formal C(sp²)–C(sp²) Cross‐Coupling Reactions

Abstract

Nitrimines are employed as powerful reagents for metal-free formal C(sp 2 )-C(sp 2 ) cross-coupling reactions. The new chemical process is tolerant of a wide array of nitrimine and heterocyclic coupling partners giving rise to the corresponding di-or trisubstituted alkenes, typically in high yield and with high stereoselectivity. This method is ideal for the metal-free construction of heterocycle-containing drug targets, such as phenprocoumon.