Nitrite-Dependent Nitric Oxide Production Pathway: Diversity of NO Production Systems

Yamasaki, Hideo; Watanabe, Naoko S.; Fukuto, Jon M.; Cohen, Michael F.

doi:10.1007/978-1-4939-0679-6_3

Cited by 9 publications

(8 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In lung injury with respiratory and/or metabolic acidosis such as in ARDS, a low local pH in the damaged capillary might allow for the chemical production of NO from nitrite. Even at a near neutral pH, nitrite can be reduced to NO in hypoxic conditions by multiple enzymes [9,11], such as deoxy-hemoglobin (deoxy-Hb) in erythrocytes, xanthine oxidoreductase (XOR) in the blood during infection, or cytochrome oxidase (COX) of mitochondrial respiratory chain (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

“…It has been known that Vit C is associated with NO production through chemical reaction with inorganic nitrite (NO 2 − ) [ 9 , 10 ]. Since the reaction is significant in acidic conditions, its physiological relevance has been considered only in gastric juice of the stomach [ 11 ]. In lung injury with respiratory and/or metabolic acidosis such as in ARDS, a low local pH in the damaged capillary might allow for the chemical production of NO from nitrite.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19

Yamasaki

2020

Nitric Oxide

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19

Yamasaki

2020

Nitric Oxide

Self Cite

View full text Add to dashboard Cite

“…In fact, A. pinnata was found to emit NO in the presence of NaN 3 and NO 2 − [21]. Nitrite is now appreciated as an endogenous NO substrate for plants [31] as well as animals [32,33]. Moreover, H 2 O 2 was found to exhibit a bimodal effect on rapid root abscission [34].…”

Section: Introductionmentioning

confidence: 99%

d-Cysteine-Induced Rapid Root Abscission in the Water Fern Azolla Pinnata: Implications for the Linkage between d-Amino Acid and Reactive Sulfur Species (RSS) in Plant Environmental Responses

et al. 2019

Self Cite

View full text Add to dashboard Cite

Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) have been proposed as universal signaling molecules in plant stress responses. There are a growing number of studies suggesting that hydrogen sulfide (H2S) or Reactive Sulfur Species (RSS) are also involved in plant abiotic as well as biotic stress responses. However, it is still a matter of debate as to how plants utilize those RSS in their signaling cascades. Here, we demonstrate that d-cysteine is a novel candidate for bridging our gap in understanding. In the genus of the tiny water-floating fern Azolla, a rapid root abscission occurs in response to a wide variety of environmental stimuli as well as chemical inducers. We tested five H2S chemical donors, Na2S, GYY4137, 5a, 8l, and 8o, and found that 5a showed a significant abscission activity. Root abscission also occurred with the polysulfides Na2S2, Na2S3, and Na2S4. Rapid root abscission comparable to other known chemical inducers was observed in the presence of d-cysteine, whereas l-cysteine showed no effect. We suggest that d-cysteine is a physiologically relevant substrate to induce root abscission in the water fern Azolla.

show abstract

“…Since the NOS reaction requires O 2 to produce NO, it does not work in anoxia or anaerobic conditions where ischemia occurs [11,12]. Nitrite-dependent NO production mechanism does work even under such conditions [11,12], and is thereby considered to be an alternative backup mechanism for NO production in our body [11,12]. In the oral cavity, nitrite (NO 2 -) is produced from nitrate (NO 3 -) through symbiotic bacterial activities [13].…”

Section: Introductionmentioning

confidence: 99%

“…In food science, nitrite contained in human diet has long been recognized for its toxicity as the causative agent of methemoglobinemia [12]. Due to the formation of mutagenic nitrosamines [16], it has also been presumed that nitrite is potentially carcinogenic [17].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Nitrite Content in Fresh Spinach Leaves: Evidence for Nitrite Formation Caused by Microbial Nitrate Reductase Activity

Watanabe¹,

Yamasaki²

2017

J Nutr Food Sci

Self Cite

View full text Add to dashboard Cite

Nitrite (NO 2 -) contained in dietary foods has long been recognized for its toxicity as the causative agent of methemoglobinemia and also as a source of mutagenic nitrosamines. Because of these potential toxicities, nitrite as well as nitrate contained in foods and drinks are strictly limited by regulations in many countries. Recent studies have offered us to update our recognition of nitrite; nitrite is an important precursor for Nitric Oxide (NO) that is required for fundamental physiological activities including vasorelaxation. Although it is well established that green vegetables contain high amounts of nitrate, there has been controversy regarding the source of nitrite accumulation in fresh green vegetables. In this study, we investigated the dynamics of nitrite and nitrate contents in spinach leaf extracts to verify the mechanisms of nitrite formation. The time course of nitrite production in leaf extracts showed a reciprocal relationship with nitrate degradation, suggesting a conversion from nitrate to nitrite. The reaction strongly depended on temperature and it was suppressed at a low temperature. Sodium tungstate, a nitrate reductase enzyme inhibitor, was effective to suppress the conversion. Pre-sterilization by autoclaving or filter sterilization completely prevented the formation of nitrite as well as degradation of nitrate. We suggest that previous reports of nitrite accumulation can be attributed to microbial nitrate reductase activities that occur during the degradation spinach leaves.

show abstract

Nitrite-Dependent Nitric Oxide Production Pathway: Diversity of NO Production Systems

Cited by 9 publications

References 92 publications

Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19

Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19

d-Cysteine-Induced Rapid Root Abscission in the Water Fern Azolla Pinnata: Implications for the Linkage between d-Amino Acid and Reactive Sulfur Species (RSS) in Plant Environmental Responses

Dynamics of Nitrite Content in Fresh Spinach Leaves: Evidence for Nitrite Formation Caused by Microbial Nitrate Reductase Activity

Contact Info

Product

Resources

About