Nitrites and nitrates in exhaled breath condensate in cystic fibrosis: relation to clinical parameters

Fila, Libor; Chládek, Jaroslav; Malý, Marek; Musil, J

doi:10.4149/bll_2013_105

Cited by 1 publication

(2 citation statements)

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“…Numerous studies show decreased NO in exhaled air from patients with CF [44]. Thomas et al [45] also reported that eNO and nNO levels were reduced in patients with CF and there was not any relationship between eNO and patients' genotype.…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Modification of Proteins in Pediatric Cystic Fibrosis with Bacterial Infections

Sadowska-Bartosz

Galiniak

Bartosz

et al. 2014

Oxidative Medicine and Cellular Longevity

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Pseudomonas aeruginosa and Staphylococcus aureus cause chronic lung infection in cystic fibrosis (CF) patients, inducing chronic oxidative stress. Several markers of plasma protein oxidative damage and glycoxidation and activities of erythrocyte antioxidant enzymes have been compared in stable CF patients chronically infected with Pseudomonas aeruginosa (n = 12) and Staphylococcus aureus (n = 10) in relation to healthy subjects (n = 11). Concentration of nitric oxide was also measured in the exhaled air from the lower respiratory tract of patients with CF. Elevated glycophore (4.22 ± 0.91 and 4.19 ± 1.04 versus control 3.18 ± 0.53 fluorescence units (FU)/mg protein; P < 0.05) and carbonyl group levels (1.9 ± 0.64, 1.87 ± 0.45 versus control 0.94 ± 0.19 nmol/mg protein; P < 0.05) as well as increased glutathione S-transferase activity (2.51 ± 0.88 and 2.57 ± 0.79 U/g Hb versus 0.77 ± 0.16 U/g Hb; P < 0.05) were noted in Pseudomonas aeruginosa and Staphylococcus aureus infected CF. Kynurenine level (4.91 ± 1.22 versus 3.89 ± 0.54 FU/mg protein; P < 0.05) was elevated only in Staphylococcus aureus infected CF. These results confirm oxidative stress in CF and demonstrate the usefulness of the glycophore level and protein carbonyl groups as markers of oxidative modifications of plasma proteins in this disease.

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Section: Discussionmentioning

confidence: 99%

“…[46]. Recently, Fila et al noted lower exhaled breath condensate nitrate concentrations in CF patients than in healthy subjects (5.8 versus 14.3 μ M, P < 0.001) [44]. de Winter-de Groot et al reported that low nNO levels are associated with S aureus colonization in the oropharynx and lower airways [47].…”

Section: Discussionmentioning

confidence: 99%