Nitro Derivatives of Naturally Occurring <i>β</i>-Asarone and Their Anticancer Activity

Shenvi, Suvarna; Diwakar, Latha; Reddy, G. Chandrasekara

doi:10.1155/2014/835485

Cited by 10 publications

(11 citation statements)

References 26 publications

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“…reported the anti-cancer assay of nitro derivatives of (β)-asarone using PC-3 (prostate cancer) cell line along with four other different types of human cancer cell lines by using MTT assay. The nitration derivative compounds of (β)-asarone exhibited an increase in activity compared to (β)-asarone confirming its cytotoxic activity in all the cell lines [34] ( Table 1 ; Figs. 4 and 5 ).…”

Section: Main Textmentioning

confidence: 63%

“… [33] Prostate cancer (PC-3 cells) Nitro derivatives of (β)-asarone (1.56–200) μM ↓ in the cell viability (MTT assay). [34] Neuroblastoma (IMR-32 cells) Cervical cancer (HeLa cells) Synovial cancer (SW982 cells) Breast cancer (MCF-7 cells) Macrophage cancer (P338D1 and J774 cells) Novel lectins from Acorus species (1.0–10) μg/ml ↓ in the cell viability ( 3 H-thymidine incorporation). [35] T cell lymphoma (A20 cells) B cell lymphoma (WEHI-279 cells) Cervical cancer (HeLa cells) Green silver nanoparticles synthesized from A. calamus (25, 50, 75, 100, 125, 150, 175 and 200 μg/ml) Anti-proliferative effect (% inhibition of cell proliferation through MTT assay).…”

Section: Main Textmentioning

confidence: 99%

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Experimental evidence for use of Acorus calamus (asarone) for cancer chemoprevention

Das

Swamy

Koti

et al. 2019

Heliyon

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Cancer is one of the major non-communicable diseases posing substantial challenges in both developing and developed countries. The options available for treatment of different cancer are associated with various limitations, including severe toxicity, drug resistance, poor outcomes and a high risk of relapse. Hence, an increased attention and necessity for screening of various phytochemicals from natural sources for superior and safer alternative has been ongoing for several decades. In recent years, phytochemicals like galantamine, erwinaze, rivastigmine, resveratrol from natural sources have been found to be important therapeutic targets for the treatment of various diseases including cancer, neurodegeneration, diabetes, and cardiovascular effects. Acorus calamus (Sweet flag), and/or its bioactive phytochemical alpha (α)-and beta (β)-asarone, is a well-known drug in the traditional system of medicine which possesses anti-tumor and chemo-preventive activities as evident from numerous pre-clinical studies both in-vitro and in-vivo . In this article, we critically review the current available scientific evidences of A. calamus and/or asarone for cancer chemoprevention based on preclinical in-vitro and in-vivo models. In addition, we also have compiled and discussed the molecular targets of mechanism(s) involved in the anti-cancer activity of A. calamus /asarone. Still, extensive in-vivo studies are necessary using various animal models to understand the molecular mechanism behind the pharmacological activity of the bioactive phytochemicals derived from A. calamus . It is strongly believed that the comprehensive evidence presented in this article could deliver a possible source for researchers to conduct future studies pertaining to A. calamus and/or its bioactive phytochemicals asarone for cancer chemoprevention.

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Section: Main Textmentioning

confidence: 63%

Section: Main Textmentioning

confidence: 99%

Experimental evidence for use of Acorus calamus (asarone) for cancer chemoprevention

Das

Swamy

Koti

et al. 2019

Heliyon

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“…10-Octadecenoic acid methyl ester decrease blood cholesterol and has antioxidant, antibacterial, and antifungal activities (Asghar & Choudahry, 2011). Asarone possess antioxidant activity (Cho, Kim, Kong, Yang, & Park, 2002;Devi, Mali, Rahee, & Belinda, 2014), adipogenesis inhibitory effect (Lee et al, 2011), antimicrobial (Devi & Ganjewala, 2009), stress reduction (Manikandan & Devi, 2005), and anticancer activities (Shenvi, Diwakar, & Reddy, 2014;Wang, Ouyang, & Lin, 2018). 9-Octadecynoic acid possess anti-inflammatory, cardiotonic, antibacterial, and analgesic activities (Kokila, Elavarasan, & Sujatha, 2016).…”

Section: Preparation Of Ligand and Oncoprotein Structurementioning

confidence: 99%

Study of fatty acid profiles in fish wastes and in silico evaluation of unsaturated fatty acids for mutant B‐Raf kinase inhibition

Nirmala

Banerjee

Imthiyaz

et al. 2019

J Food Process Engineering

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Fish wastes include heads, intestines, fins, tails, and bones that are discarded in large quantity from fish processing industries. Substantial quantity of lipids and proteins can be extracted from these fish wastes to meet the dietary needs and to treat various ailments in humans. In the present study, the fish wastes of catla, rohu, and mixed fish wastes from Indian major carps are collected and analyzed for the fatty acid profile and protein content. The monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) obtained are analyzed for mutant B‐Raf kinase, a protooncoprotein inhibition using PATCHDOCK, and the best docked result is analyzed with PDBsum. The results showed that the concentration of saturated fatty acid was higher than that of MUFAs and PUFAs. The protein content was 0.58 mg/ml in Sample 1, 0.55 mg/ml in Sample 2, and 2.88 mg/ml in Sample 3. The docking study showed that MUFAs and PUFAs bound in the active site of the B‐Raf kinase domain with varied nonbonded interactions that may inhibit its activity, thus showing anticancerous properties. Practical applications Fishes are one of the major sources of balanced and nutritious diet for human beings. Huge tons of Indian major carps (IMCs) are discarded as wastes from fish processing industries and commercial markets that are rich in nutritive compounds like proteins, essential fatty acids, carbohydrates, vitamins, and so forth. These wastes can be recycled and reused for many pharmacological properties. Unsaturated fatty acids were found to have beneficial properties for humans. The selected MUFAs and PUFAs from fish wastes of IMCs showed inhibition of mutant B‐Raf kinase, a protein, associated with the activation of the Ras/Raf/MEK/ERK signaling pathway leading to cancer. Thus, these compounds may be used as cancer preventive agents and the study may lead to a novel approach to design drug molecules with nonbonded interactions in the protein–lipid interface.

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“…Studies have shown that βasarone has anti-cancer functions in colorectal cancer (Liu Wang et al, 2013;Zou et al, 2012), gastric cancer (Wu et al, 2015), lung cancer (Wang Ouyang et al, 2018), lymphoma (Lv et al, 2019) hepatocellular arcinoma (Stegmuller et al, 2018) and glioblastomas (Li L et al, 2018;Qi et al, 2015;Wang et al, 2017). It has been reported that nitro derivatives of β-asarone exert also anti-proliferative effects in prostate cancer cells (PC-3), neuroblastoma (IMR-32) cells, cervical cancer (HeLa) cells, synovial cancer (SW982) cells and breast cancer (MCF-7) cells (Shenvi et al, 2014). Aqueous and ethanolic extracts of A. calamus has been also reported to reduce the cell viability in breast cancer MDA-MB-435S cells and liver carcinoma Hep3B cells (Venkatadri, Guha, Kumar, & Lazar, 2009).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Anti-Cancer Effects of B-asaron and Etoposide in MCF-7 Breast Cancer Cells

Ak¹,

Yılmaz²,

Kaygusuz³

et al. 2022

IJIASR

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Currently, the options available for the treatment of various cancers including breast cancer, are associated with several limitations such as severe toxicity, drug resistance, poor prognosis, and high risk of recurrence. Therefore, there appears to be an increasing interest and necessity in investigating various phytochemicals from natural sources for a superior and safer alternative treatment strategy. The bioactive phytochemical alpha (α) and beta (β)-asarone from Acorus calamus is a traditional medicine system that has been shown to have anti-tumor and chemo-inhibitory activities in numerous preclinical studies both in vitro and in vivo.Various experimental studies with human malignant cell lines and animal models have also confirmed the anti-tumor and anticancer activities of β-asarone. In this study, we aimed to investigate the anti-cancer effects of β-asarone alone or together with etoposide buy measuring cellular responses such as cell viablity, cell cycle arrest and apoptosis using breast cancer cell line MCF-7 cells. In order to get insight in to the mechanism, we also tested the expression of of NF-κB / p65 activity and the expression of Bcl-2 family member pro-apoptotic Bax protein together with p53 and p21 activities in response to β-asarone alone or together with etoposide treatment. As a result, it was concluded that the use of β-asarone alone in breast cancer cells is effective in reducing cell viability, but when used together with Etoposide, it does not cause a synergistic effect. Here we suggest that that in particular activation of NF-kB/p65 may be lead resistance to etoposide treatment.

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Nitro Derivatives of Naturally Occurring β-Asarone and Their Anticancer Activity

Cited by 10 publications

References 26 publications

Experimental evidence for use of Acorus calamus (asarone) for cancer chemoprevention

Experimental evidence for use of Acorus calamus (asarone) for cancer chemoprevention

Study of fatty acid profiles in fish wastes and in silico evaluation of unsaturated fatty acids for mutant B‐Raf kinase inhibition

Investigation of the Anti-Cancer Effects of B-asaron and Etoposide in MCF-7 Breast Cancer Cells

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