Nitrofurantoin in Renal Failure

Glascock, Harold W.

doi:10.7326/0003-4819-69-5-1077

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2013

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“…10,11 Furthermore, a lower CrCl cutoff point of 30 or 40 mL/min is applied by some investigators and clinicians. 12,13 We evaluated the evidence behind nitrofurantoin contraindication in patients with a CrCl less than 60 mL/min.…”

Section: Responsementioning

confidence: 99%

Nitrofurantoin Contraindication in Patients with a Creatinine Clearance Below 60 mL/min: Looking for the Evidence

Oplinger

Andrews

2013

Ann Pharmacother

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Data supporting the contraindication of nitrofurantoin for patients with a CrCl less than 60 mL/min are nonexistent. Well-designed clinical trials with urinary concentration information and clinical end points on patients with various degrees of renal impairment are much needed. Until such a study becomes available, the limited data available would support considering using this drug in patients with a CrCl of 40 mL/min or higher.

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Section: Responsementioning

confidence: 99%