Nitrofurantoin Pulmonary Complications

Kursh, Elroy D.; Mostyn, E. M.; Persky, Lester

doi:10.1016/s0022-5347(17)59490-2

Cited by 24 publications

(8 citation statements)

References 10 publications

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“…[4] compiled and reviewed approximately 200 cases of pulmonary reactions to nitrofuran toin over a 10-year period. A fatal reaction to nitrofurantoin was reported in 1975 [5], Despite the abundance of reports, the exact incidence of these reactions is unknown.…”

Section: Discussionmentioning

confidence: 99%

Adult Respiratory Distress Syndrome Associated with Acute Nitrofurantoin Toxicity

Israel¹,

Gross²,

Bomba³

1980

Respiration

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A case of adult respiratory distress syndrome associated with nitrofurantoin use is described. The patient was successfully managed with continuous positive airway pressure (CPAP) through a tightly fitting face mask; clinical deterioration followed discontinuation of the CPAP, with improvement occurring when it was restarted. Acute nitrofurantoin pleuropulmonary reactions are reviewed, and CPAP by face mask is discussed

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Section: Discussionmentioning

confidence: 99%

Adult Respiratory Distress Syndrome Associated with Acute Nitrofurantoin Toxicity

Israel¹,

Gross²,

Bomba³

1980

Respiration

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“…[25][26][27][28] The mean delay before onset of chronic pulmonary toxicity has been reported as 30 months, 29 and this condition lacks a dose-response relationship, occurs predominantly in women, and is often slow to resolve. 9 Common manifestations have included interstitial pneumonitis and fibrosis, which may lead to shortness of breath and cough (often dry).…”

Section: J H P -mentioning

confidence: 99%

Nitrofurantoin-Associated Lung and Liver Toxicity Leading to Liver Transplantation in a Middle-Aged Patient

Kiang

Ford

Yoshida

et al. 2011

CJHP

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“…Among the reported cases, a limited number of authors described lung scintigraphic findings in this dis -o r d e r . [3][4][5] been reported. We report a case of acute pulmonary nitrofurantoin reaction with an abnormal ventilation and normal perfusion scan.…”

Section: Introductionmentioning

confidence: 99%

Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction

et al. 1997

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A 67-yr-old woman with a history of myocardial infarct was admitted to emergency for marked dyspnea, nonproductive cough, nausea and fever. The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ventilation and Tc-99m-macroaggregated albumin (MAA) perfusion scans were performed to rule out pulmonary embolism. Bilateral multiple ventilation defects with normal perfusion was observed. The patient had been taking nitrofurantoin for four days for a bladder infection. Hypersensitivity to nitrofurantoin was suspected and the drug was discontinued. An antihistaminic and anxiolytic medication was started. The majority of the clinical symptoms disappeared within 24 hours. The control chest X-rays disclosed a marked improvement. Ventilation and perfusion scans obtained 48 hours after nitrofurantoin withdrawal were normal. The drug-related pulmonary reactions should be taken into account in patients on medication. Reversible ventilation defects can be the only lung-scintigraphic finding encountered in acute pulmonary nitrofurantoin reaction.

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Nitrofurantoin Pulmonary Complications

Cited by 24 publications

References 10 publications

Adult Respiratory Distress Syndrome Associated with Acute Nitrofurantoin Toxicity

Adult Respiratory Distress Syndrome Associated with Acute Nitrofurantoin Toxicity

Nitrofurantoin-Associated Lung and Liver Toxicity Leading to Liver Transplantation in a Middle-Aged Patient

Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction

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