Nitrofurantoína y enfermedad pulmonar intersticial de rápida resolución

Viejo, Miguel Ángel Núñez; Montes, Ana; Montes, Javier Velasco; Gómez-Román, Javier; Ibarbia, C. García; Hernández, José L.

doi:10.1016/j.arbres.2008.05.009

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…Patients with both acute and chronic nitrofurantoin-induced pulmonary toxicity generally have a good prognosis including those patients with lung biopsy or radiographic evidence of chronic interstitial lung disease [2,5,15]. Patients with nitrofurantoin-induced interstitial lung disease with severely distorted bronchial architecture and honeycombing observed on imaging may benefit from a transbronchial biopsy to assess the reversibility of pulmonary lesions [16]. Findings of acute or subacute interstitial pneumonitis on lung biopsy usually suggest a good prognosis, and these patients usually respond well to prednisone therapy in addition to discontinuation of nitrofurantoin [16].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with nitrofurantoin-induced interstitial lung disease with severely distorted bronchial architecture and honeycombing observed on imaging may benefit from a transbronchial biopsy to assess the reversibility of pulmonary lesions [16]. Findings of acute or subacute interstitial pneumonitis on lung biopsy usually suggest a good prognosis, and these patients usually respond well to prednisone therapy in addition to discontinuation of nitrofurantoin [16].…”

Section: Discussionmentioning

confidence: 99%

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Nitrofurantoin-associated Acute Pulmonary Toxicity Mimicking Severe Sepsis with Significantly Elevated Procalcitonin

Khan

Ansari

Siddiqui

et al. 2019

Cureus

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Nitrofurantoin is a commonly used treatment for urinary tract infections with a risk for pulmonary toxicity. We report a case of a 48-year-old woman on a prophylactic regimen of nitrofurantoin who exhibited classic signs of bacterial sepsis including elevated procalcitonin (PCL) and C-reactive protein (CRP) levels two days post-nephrolithotripsy. The microbial analysis did not reveal an infectious cause for the initial symptoms and, subsequently, the patient developed a dry cough, fever, chills, and transient hypoxemia requiring supplemental oxygen. Pulmonary imaging revealed significant abnormal features inconsistent with the patient's symptoms which indicated an inflammatory/immune reaction to nitrofurantoin. Treatment discontinuation improved the patient's symptoms and reduced PCL and CRP levels to within normal limits. A high index of suspicion for nitrofurantoin-associated pulmonary toxicity is warranted for patients on a regimen of nitrofurantoin who exhibit severe pulmonary symptoms and elevated PCL and CRP levels with no corresponding infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nitrofurantoin-associated Acute Pulmonary Toxicity Mimicking Severe Sepsis with Significantly Elevated Procalcitonin

Khan

Ansari

Siddiqui

et al. 2019

Cureus

View full text Add to dashboard Cite

show abstract

“…Nitrofurantoin is associated with acute or subacute pneumonitis (ILD) characterized generally with bilateral and symmetric pulmonary opacities. Pulmonary fibrosis, eosinophilic pneumonia, or pleuropathy (discussed later) may be present with restrictive lung dysfunction and hypoxemia, which usually resolve after the drug is discontinued [172][173][174].…”

Section: Drug-induced Parenchymal and Interstitial Lung Disease (Ild)mentioning

confidence: 99%