Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy

Wang, Hui; Mu, Qingxin; Wang, Kui; Revia, Richard A.; Yen, Charles; Gu, Xinyu; Tian, Bowei; Li, Jun; Zhang, Miqin

doi:10.1016/j.apmt.2018.11.011

Cited by 160 publications

(141 citation statements)

References 43 publications

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“…Previous studies pointed out the reduced tumorigenicity associated with DMF. Therefore, the functionalization of GQDs with DMF may be of interest for potential biomedical applications in cancer research [28]. Furthermore, the coadministration of GQDs and doxorubicin (Dox) is investigated.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

et al. 2020

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Glioblastoma is the most aggressive and lethal brain cancer. Current treatments involve surgical resection, radiotherapy and chemotherapy. However, the life expectancy of patients with this disease remains short and chemotherapy leads to severe adverse effects. Furthermore, the presence of the blood–brain barrier (BBB) makes it difficult for drugs to effectively reach the brain. A promising strategy lies in the use of graphene quantum dots (GQDs), which are light-responsive graphene nanoparticles that have shown the capability of crossing the BBB. Here we investigate the effect of GQDs on U87 human glioblastoma cells and primary cortical neurons. Non-functionalized GQDs (NF-GQDs) demonstrated high biocompatibility, while dimethylformamide-functionalized GQDs (DMF-GQDs) showed a toxic effect on both cell lines. The combination of GQDs and the chemotherapeutic agent doxorubicin (Dox) was tested. GQDs exerted a synergistic increase in the efficacy of chemotherapy treatment, specifically on U87 cells. The mechanism underlying this synergy was investigated, and it was found that GQDs can alter membrane permeability in a manner dependent on the surface chemistry, facilitating the uptake of Dox inside U87 cells, but not on cortical neurons. Therefore, experimental evidence indicates that GQDs could be used in a combined therapy against brain cancer, strongly increasing the efficacy of chemotherapy and, at the same time, reducing its dose requirement along with its side effects, thereby improving the life quality of patients.

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Section: Introductionmentioning

confidence: 99%

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

et al. 2020

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“…The as-prepared B-N-CDs showed a photothermal efficiency of 32.3%, which is lower than that of the red emissive dots of Sun and coworkers [8], but these CDs were slightly more cytotoxic for SF-763 cells. In fact, SF-763 cells treated with B-N-CDs at 100 μg/mL for 2 h, showed 96% mortality when irradiated with NIR light (808 nm, 1.5 W/cm 2 ) for 5 min [97]. Astonishingly, non-irradiated cells treated with B-N-CDs displayed viability of 90%.…”

Section: Carbon Dots As Photothermal Agentsmentioning

confidence: 97%

“…demonstrated near infrared-emissive CDs with a peak at 1000 nm. These CDs were doped with nitrogen and boron in order to achieve long wavelength emission and induce higher tissue penetration [97]. The as-prepared B-N-CDs showed a photothermal efficiency of 32.3%, which is lower than that of the red emissive dots of Sun and coworkers [8], but these CDs were slightly more cytotoxic for SF-763 cells.…”

Section: Carbon Dots As Photothermal Agentsmentioning

confidence: 99%

“…The authors tested these Ce6-CDs on three cancer lines (4T1, HepG2, HeLa) and found no cytotoxic effects, while upon laser irradiation (671 nm, 500 mW cm −2 ) for 20 min at a concentration of 200 μg/ml the mortality rate varied between 80 and 90% for the different cancer lines [99]. Despite the fact that the mortality rate is not the highest found in the literature [97], the authors managed to induce high mortality rates in cancer cells by using low irradiation power and a small amount of Ce6 [99]. These results indicate that not only the Ce6-CDs can be employed for in vivo studies, but also for clinical applications since they treat the tumor area in a more effective and precise way than other already reviewed studies.…”

Section: Carbon Dots As Photothermal Agentsmentioning

confidence: 99%

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Advances in fluorescent carbon dots for biomedical applications

Koutsogiannis

Thomou

Stamatis

et al. 2020

Advances in Physics: X

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Carbon Dots are an emerging class of carbon-based nanoparticles, which since their discovery have attracted tremendous attention because of their exceptional fluorescent, chemical and mechanical properties as well as high photostability and biocompatibility. This unique combination of outstanding characteristics, together with the ease with which they can be synthesized, qualify carbon dots as highly promising materials for applications in electronics and biology, in particular, for biosensing, bioimaging, biotherapy and drug delivery. In this review, we present some of the most recent applications of carbon dots in biology and medicine, concentrating on their fluorescence properties, biocompatibility and efficiency; we also discuss how improvements could prompt their use in human studies. We illustrate how carbon dots, prepared through several facile and costeffective methods by either the bottom-up or the top-down route, can be used for imaging cells and bacteria and as sensing probes of metal cations. Moreover, we explain how their astonishing versatility has given rise to new biotherapy methods especially in the field of cancer theranostics.

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“…It could simultaneously produce NIR fluorescence and use as photoacoustic imaging in tumor diagnosis with advanced PTT effect. Recently, wang et al also successfully applied nitrogen‐ and boron‐doped GQDs (N‐B‐GQDs) for near‐infrared second window imaging and photothermal therapy …”

Section: Application In Bioimaging In Vitromentioning

confidence: 99%

Graphene Quantum Dots for Optical Bioimaging

Dong

et al. 2019

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Graphene quantum dots (GQDs) have shown great potential in bioimaging applications due to their excellent biocompatibility, low cytotoxicity, feasibility for surface functionalization, physiological stability, and tunable fluorescence properties. This Review first introduces the intriguing optical properties of GQDs that are suitable for biological imaging, and is followed by the GQDs' synthetic strategies. The emergent and latest development methods for tuning GQDs' optical properties are further described in detail. The recent advanced applications of GQDs in vitro, particularly in cell imaging, targeted imaging, and theranostic nanoplatform fabrication, are included. The applications of GQDs for in vivo bioimaging are also covered. Finally, the Review is concluded with the challenges and prospectives that face this nascent yet exciting field.

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Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy

Cited by 160 publications

References 43 publications

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

Advances in fluorescent carbon dots for biomedical applications

Graphene Quantum Dots for Optical Bioimaging

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