Nitrogen and sulphur doped carbon dot: An excellent biocompatible candidate for in-vitro cancer cell imaging and beyond

Ghosh, Trisita; Nandi, Suvendu; Bhattacharyya, Swarup Krishna; Ghosh, Suman Kumar; Mandal, Mahitosh; Banerji, P.; Das, Poushali

doi:10.1016/j.envres.2022.114922

Cited by 32 publications

(10 citation statements)

References 49 publications

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“…In addition, CDs have the advantages of abundant sources, a variety of synthesis techniques, simple large-scale synthesis, and functionalization. Consequently, they have promising application prospects in a variety of fields, including bio-imaging [31,32], sensing [33,34], catalysis [35,36], energy conversion [37,38], and biomedicine [39,40].…”

Section: Cds: Nanomaterials Used As Antibacterial Agentsmentioning

confidence: 99%

Synthesis, properties and mechanism of carbon dots-based nano-antibacterial materials

Zhu,

Peng,

Liang

et al. 2023

Biomed. Mater.

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Antibiotics play an important role in the treatment of diseases, but bacterial resistance caused by their widespread and unreasonable use has become an urgent problem in clinical treatment. With the rapid advancement of nanoscience and nanotechnology, the development of nanomedicine has been transformed into a new approach to the problem of bacterial resistance. As a new type of carbon-based nanomaterial, carbon dots (CDs) have attracted the interest of antibacterial researchers due to their ease of preparation, amphiphilicity, facile surface functionalization, and excellent optical properties, among other properties. This article reviewed the synthesis methods and properties of various CDs and their composites in order to highlight the advancements in the field of CDs-based antibacterial agents. Then we focused on the relationship between the principal properties of CDs and the antibacterial mechanism, including the following: (1) The physical damage caused by the small size, amphiphilicity, and surface charge of CDs. (2) Photogenerated electron transfer characteristics of CDs that produce reactive oxygen species (ROS) in themselves or in other compounds. The ability of ROS to oxidize can lead to the lipid peroxidation of cell membranes, as well as damage proteins and DNA. (3) The nanoenzyme properties of CDs can catalyze reactions that generate ROS. (4) Synergistic antibacterial effect of CDs and antibiotics or other nanocomposites. Finally, we look forward to the challenges that CDs-based nanocomposites face in practical antibacterial applications and propose corresponding solutions to further expand the application potential of nanomaterials in the treatment of infectious diseases, particularly drug-resistant bacterial infections.

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Section: Cds: Nanomaterials Used As Antibacterial Agentsmentioning

confidence: 99%

Synthesis, properties and mechanism of carbon dots-based nano-antibacterial materials

Zhu,

Peng,

Liang

et al. 2023

Biomed. Mater.

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“…Recently, tremendous progress has been observed in the field of magnetic metal-doped carbon dots as an efficient FL/MR dual modal bioimaging probe. , In the MRI field, a combination of multiple imaging models rather than single model imaging tools provides more detailed as well as accurate diagnostic information. Nowadays, the T1–T2 dual modal imaging technique has attracted tremendous attention due to its more precise diagnostic information by incorporation of both contrast agents into the nanoparticle system. − Doping with the T1 contrast agent can give T1 imaging data with high tissue resolution along with T2 imaging data with a higher feasibility of detection . Thus, considering the synergistic effect of both contrast agents, it will be very effective to develop a dual modal imaging system integrating both into one single device, which will be much more effective as well as time-efficient.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots for Multiuse Platform: Intracellular pH Sensing and Complementary Intensified T1–T2 Dual Imaging Contrast Nanoprobes

Ghosh,

Nandi,

Girigoswami

et al. 2024

ACS Biomater. Sci. Eng.

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Measurement of pH in living cells is a great and decisive factor for providing an early and accurate diagnosis factor. Along with this, the multimodal transverse and longitudinal relaxivity enhancement potentiality over single modality within a single platform in the magnetic resonance imaging (MRI) field is a very challenging issue for diagnostic purposes in the biomedical field of application. Therefore, this work aims to design a versatile platform by fabricating a novel nanoprobe through holmium-and manganese-ion doping in carbon quantum dots (Ho−Mn−CQDs), which can show nearly neutral intracellular pH sensing and MRI imaging at the same time. These manufactured Ho−Mn−CQDs acted as excellent pH sensors in the near-neutral range (4.01−8.01) with the linearity between 6.01 and 8.01, which could be useful for the intracellular pH-sensing capability. An innumerable number of carboxyl and amino groups are present on the surface of the prepared nanoprobe, making it an excellent candidate for pH sensing through fluorescence intensity quenching phenomena. Cellular uptake and cell viability experiments were also executed to affirm the intracellular accepting ability of Ho−Mn−CQDs. Furthermore, with this pH-sensing quality, these Ho−Mn−CQDs are also capable of acting as T1−T2 dual modal imaging contrast agents in comparison with pristine Ho-doped and Mn-doped CQDs. The Ho−Mn−CQDs showed an increment of r1 and r2 relaxivity values simultaneously compared with only the negative contrast agent, holmium in holmium-doped CQDs, and the positive contrast agent, manganese in manganese-doped CQDs. The above-mentioned observations elucidate that its tiny size, excitation dependence of fluorescence behavior, low cytotoxicity, and dual modal contrast imaging capability make it an ideal candidate for pH monitoring in the near-neutral range and also as a dual modal MRI imaging contrast enhancement nanoprobe at the same time.

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“…toxicity which varied due to the content of hydrogen, oxygen, and nitrogen-containing functional groups. Recently, photoluminescent heteroatom-doped CDs are reported for cancer cell imaging which are prepared from urea [38]. However, it is also reported that metal and non metal doped CDs shows high photoluminescent properties in solution where magnesium doped to tamarind extract combined with nitrogen doping, yield an extremely high quantum yield [39].…”

Section: Introductionmentioning

confidence: 99%

Facile cost-effective green synthesis of carbon dots: selective detection of biologically relevant metal ions and synergetic efficiency for treatment of cancer

Maity,

Modak,

Tomar

et al. 2024

Biomed. Mater.

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A facile cost-effective green synthesis approach has been used to synthesize carbon-dot (CDs) from the Kernel part of the Azadirachta Indica seeds and investigated their fluorescent and metal ions sensing capability and also used for the delivery of drugs. Metallic ions such as Ca2+, K+, Na+, Fe3+, and Zn2+ which are biologically important for many reactions and are selectively detected through the novel CDs. The resultant dot size of CDs (~ 4 nm) is useful to eliminate the ‘Achilles heel’ problems, which is associated with the Zn2+ in the body and its detection is a very challenging task. It is found that the sensitivity of CDs for the detection of Zn2+ can be regulated by using different solvents. These CDs can also be used as a sensing probe for the selective detection of Fe3+ at a very low concentration of solution (~ 5 µM). The synthesis method of CDs reported here is cost-effective, very fast and it is highly selective towards Fe3+ and Zn2+. Due to the fast response capability of these CDs, logic gate operation is achieved and it provides a new understanding to construct potential next-generation molecular devices for the detection of different biomolecules with high selectivity. Additionally, these CDs are biocompatible against normal healthy cells, capable of loading small biomolecules and drugs due to their porous nature, and exhibited potential impact for breast cancer therapy. It is observed that a significant synergic therapeutic effect of CDs loaded with DOX against breast cancer cells is very promising. Thus, the CDs reported herein in this work have been synthesized through a green synthesis approach and can be used as a molecular probe for the detection of metal ions as well as for drug delivery applications.

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Nitrogen and sulphur doped carbon dot: An excellent biocompatible candidate for in-vitro cancer cell imaging and beyond

Cited by 32 publications

References 49 publications

Synthesis, properties and mechanism of carbon dots-based nano-antibacterial materials

Synthesis, properties and mechanism of carbon dots-based nano-antibacterial materials

Carbon Dots for Multiuse Platform: Intracellular pH Sensing and Complementary Intensified T1–T2 Dual Imaging Contrast Nanoprobes

Facile cost-effective green synthesis of carbon dots: selective detection of biologically relevant metal ions and synergetic efficiency for treatment of cancer

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