Nitrogen Balance in Experimental Lysine Deficiency in Man.

Albanese, Anthony A.; Holt, L. Emmett; Brumback, Joseph E.; Hayes, Marjorie; Kajdi, C. N.; Wangerin, Dorothy M.

doi:10.3181/00379727-48-13441

Cited by 24 publications

(3 citation statements)

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“…On the other hand, Burroughs, Burroughs & Mitchell (1940), using mixtures of essential amino-acids, found that the lack of lysine in the diet of adult rats led to a small or negligible N balance; these authors concluded that lysine is probably not essential for maintenance of N equilibrium in the rat. From experiments in which deaminized casein was fed to volunteers (Albanese, Holt, Brumback, Hayes, Kajdi & Wangerin, 1941) it was deduced that lysine was essential for the maintenance of N equilibrium in humans; these experiments are, however, not conclusive, since deaminized casein is toxic and its deleterious effects are specifically relieved by lysine (Hogan, Powell & Guerant, 1941). In view of the conflict of opinion it was decided to reinvestigate the problem.…”

Section: I945mentioning

confidence: 99%

The lysine requirements of the adult rat

Neuberger

Webster

1945

Biochemical Journal

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Section: I945mentioning

confidence: 99%

The lysine requirements of the adult rat

Neuberger

Webster

1945

Biochemical Journal

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“…Osborne & Mendel [21] were the first to demonstrate that the amino acid lysine was essential for growth in rats, and 27 years later Albanese and collaborators [3] showed it to be indispensable for growth in human beings. Several workers have investigated the 24 hour requirement of lysine in the human being.…”

Section: Introductionmentioning

confidence: 99%

Cystinuria in Sweden:VIII. A Case of Coeliac Disease Associated with Cystine‐Lysinuria

Hambræus

Hevesy

1964

Acta Paediatrica

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“…From the latter preparation most of the residual cystine was also removed by adsorption on norit. When the former hydrolyzate was fed in diets fortified with tryptophane, equilibrium was not at tained until lysine was added (7,8). Supplementation of the latter hydrolyzate with tryptophane, methionine, and cystine provided a mix ture adequate for maintenance.…”

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The Metabolism of Proteins and Amino Acids

Berg¹

1944

Annu. Rev. Biochem.

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In the compilation of this review an attempt has been made to give appropriate recognition· to the current interest in normal and emer gency nutrition, by discussing such aspects as the amino acid needs of the human subject, the synthesis of blood proteins, intravenous ali mentation, and the use of urea by ruminants. References to papers in the fields of plant and bacterial metabolism have been largely omitted. During the year many delayed foreign journals have become available, but their arrival has been erratic and it has not been possible to fill some of the gaps. Throughout the review 1 and d have been used in the configurational sense.Essential amino acids.-The amino acid requirements for main tenance in the adult human subject have recently been tested with protein hydrolyzates and with mixtures of purified amino acids as the chief or sole source of protein nitrogen. Studies of the former type have come chiefly from the laboratory of Holt. Nitrogen equilibrium was readily maintained on an enzymic hydrolyzate of casein, but this was not possible with acid-hydrolyzed casein until tryptophan . �had been added (1, 2). Two other acid hydrolyzates were prepared, one from casein which had been deaminized to destroy the lysine (3) and the other from casein which had been oxidized with hydrogen perox ide (4, 5) to convert the methionine to the corresponding biologically inactive sulfone (6) which was removed as the insoluble calcium sul fonate. From the latter preparation most of the residual cystine was also removed by adsorption on norit. When the former hydrolyzate was fed in diets fortified with tryptophane, equilibrium was not at tained until lysine was added (7, 8). Supplementation of the latter hydrolyzate with tryptophane, methionine, and cystine provided a mix ture adequate for maintenance. Removal of the methionine produced negative nitrogen balances and loss of body weight; its restoration re-established nitrogen equilibrium in a few days, but did not increase the body weight. 0 The inconsistent results obtained by the omission of cystine were considered to suggest that cystine was essential, but this conclusion was t.bought to require confirmation (9). An abstract 239 Annu. Rev. Biochem. 1944.13:239-262. Downloaded from www.annualreviews.org Access provided by Technische Universiteit Eindhoven on 02/02/15. For personal use only.Quick links to online content Further ANNUAL REVIEWS

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Nitrogen Balance in Experimental Lysine Deficiency in Man.

Cited by 24 publications

References 0 publications

The lysine requirements of the adult rat

The lysine requirements of the adult rat

Cystinuria in Sweden:VIII. A Case of Coeliac Disease Associated with Cystine‐Lysinuria

The Metabolism of Proteins and Amino Acids

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