Nitrogen-Containing Molecules: Natural and Synthetic Products including Coordination Compounds

Matiadis, Dimitris; Halevas, Eleftherios

doi:10.3390/m1282

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…To test the effect of substituted N1 and C2 benzene fused imidazole ring on antifungal activity, the benzimidazole (imidazole ring fused to the benzene ring with a large conjugated system and superior electro rich properties in comparison to triazole and imidazole) moiety, a bioisosteres, was chosen to replace triazole of fluconazole. (Matiadis and Halevas 2021) The benzimidazole ring could easily engage with the active target in a biological system via non-covalent interactions like hydrogen bonds, stacking, hydrophobic effect, and Vander Waals force. (Marinescu 2019) The addition of functional groups to the benzimidazole ring resulted in a binding site contact with an additional binding region.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Anti-Fungal Properties of Carbohydrates Derivatives over Commercial Antifungal Drugs

Meghana¹,

Sivaprasad²

2023

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Aim: The goal is to compare the anti-fungal characteristics of carbohydrates derivatives to commercial antibiotics, and docking will be used to see how the ligand, protein, and anti-fungal interact molecularly. Materials and methods: The protein structure was obtained from the PDB (protein data bank) website, while the ligand structure was obtained from the NCBI-PubChem website. The fungus from aspergillus parasiticus (3HQR) as a protein, gluconolactone as a ligand, and benzimidazoles as an antifungal are the three different types of chemicals employed for docking. The genuine nature of protein chemical structure may be found on the PubChem website, while the remaining two chemical structures of ligand and antifungal can be found on the PDB website. Result: To determine whether or not the interaction between the protein molecule of the fungus from aspergillus parasiticus (3HQR) and the antifungal benzimidazoles is correct. The independent sample t-test was used to compare binding affinity using SPSS software. Significant difference, one-sided p values are.18-.001, and the two-sided p-value is.689 -.001, according to statistics. Conclusion: The antifungal benzimidazoles appear to be more specific and selective in their antifungal activity against the target protein.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Anti-Fungal Properties of Carbohydrates Derivatives over Commercial Antifungal Drugs

Meghana¹,

Sivaprasad²

2023

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“…N -Heterocycles are molecular frameworks in a broad range of highly potent natural and synthetic biologically active molecules . Indeed, approximately 82% of small-molecule drugs approved by the US FDA are nitrogenous heterocyclic compounds .…”

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confidence: 99%

Acid-Promoted Cyclization of α-Azidobenzyl Ketones through C═N Bond Formation: Synthesis of 6-Substituted Quinoline Derivatives

Zheng,

Luo,

et al. 2024

Org. Lett.

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An acid-promoted cyclization of α-azidobenzyl ketones has been developed for the synthesis of 6-substituted quinoline derivatives. A variety of synthetically useful 6-OTf or -OMs quinoline derivatives were obtained in moderate to good yields. The reaction proceeds via C�N bond formation without organophosphine, providing convenient access to structurally interesting and synthetically important 6-substituted quinoline derivatives in moderate to good yields. A mechanistic perspective that is different from the traditional intramolecular Schmidt reaction has been proposed.

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Metal‐Free [2+3] Dipolar Cycloaddition/Denitration Cascade between Nitroalkenes and α‐Diazoesters: Regioselective Access to Functionalized NH−Pyrazoles

Kumar,

Ray,

Saha

et al. 2024

Asian J Org Chem

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An efficient one‐pot synthesis of 1H‐pyrazoles has been realized via cascade cyclocondensation of β‐nitroalkenes as C2 synthon with α‐diazoesters as C1N2 unit. The reaction proceeds via concomitant formation of two new (C‐N & C‐C) bonds in one stretch leading to ethyl 5‐nitro‐4‐phenyl‐4,5‐dihydro‐3H‐pyrazole‐3‐carboxylate intermediate, which undergoes base mediated denitration enabling the formation of NH‐pyrazoles. This protocol not only features easy operation, catalyst‐free conditions, good to high yields, wide scope and late‐stage functionalization, but also opens up a new avenue for synthetically demanding and structurally non‐traditional pyrazoles. A combination of experimental and DFT studies provide evidence for the proposed mechanism.

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Nitrogen-Containing Molecules: Natural and Synthetic Products including Coordination Compounds

Abstract: Nitrogen constitutes one of the most crucial elements in synthetic compounds, both in organic and in coordination chemistry [...]

Cited by 4 publications

References 22 publications

Comparative Analysis of Anti-Fungal Properties of Carbohydrates Derivatives over Commercial Antifungal Drugs

Comparative Analysis of Anti-Fungal Properties of Carbohydrates Derivatives over Commercial Antifungal Drugs

Acid-Promoted Cyclization of α-Azidobenzyl Ketones through C═N Bond Formation: Synthesis of 6-Substituted Quinoline Derivatives

Metal‐Free [2+3] Dipolar Cycloaddition/Denitration Cascade between Nitroalkenes and α‐Diazoesters: Regioselective Access to Functionalized NH−Pyrazoles

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