Nitrogen dioxide and related free radicals: electron-transfer reactions with organic compounds in solutions containing nitrite or nitrate

Forni, Luigi G.; Mora-Arellano, Victor O.; Packer, John E.; Willson, R. L.

doi:10.1039/p29860000001

Cited by 131 publications

(79 citation statements)

References 10 publications

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“…The product °NO2 reacts efficiently with thiols [36] with an estimated overall rate constant in aqueous solution ofk 4 > 5 x 108 M-Is • -1 [37], where reaction 4 proceeds via intermediary adducts such CysS°(NO2)H and S-nitroso thiols [36].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca‐ATPase of rat skeletal muscle during aging: a peroxynitrite‐mediated process?

Viner¹,

Ferrington²,

Hühmer³

et al. 1996

FEBS Letters

132

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The SR Ca-ATPase in skeletal muscle SR vesicles isolated from young adult (5 months) and aged (28 months) rats was analyzed for nitrotyrosine. Only the SERCA2a isoform contained significant amounts with approximately one and four nitrotyrosine residues per young and old Ca-ATPase, respectively. The in vitro exposure of SR vesicles of young rats to peroxynitrite yielded selective nitration of the SERCA2a Ca-ATPase even in the presence of excess SERCAla. No nitration was observed during the exposure of SR vesicles to nitric oxide in the presence of 02. These data suggest the in vivo presence of peroxynitrite in skeletal muscle. The greater nitrotyrosine content of SERCA2a from aged tissue implies an age-associated increase in susceptibility to oxidation by this species.

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Section: Discussionmentioning

confidence: 99%

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca‐ATPase of rat skeletal muscle during aging: a peroxynitrite‐mediated process?

Viner¹,

Ferrington²,

Hühmer³

et al. 1996

FEBS Letters

132

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“…Although the reaction of NO 3 2-with TcO 4 -is considerably slower than the other electron transfer reactions of NO 3 2-, the reaction of NO 3 2-with TcO 4 -is much faster than the hydrolysis of NO 3 2- , Forni 1986). The significance of this difference in rate is the relatively high efficiency of the reduction of TcO 4 -in concentrated nitrate solution provided that molecules capable of scavenging O -are present.…”

Section: G(−tcomentioning

confidence: 99%

“…Since the C-centered radicals produced during radiolysis of IDA and NTA are unreactive towards technetium species, these molecules represent excellent scavengers for use in studying the radiolysis of technetium in the presence of nitrate. The basic radiation chemistry of nitrate is given in equations 3.8-3.10 , Daniels 1967, Daniels 1969a, Daniels 1969b, Forni 1986 -) is then given by equation 3.12 where k n is the rate constant for the reaction given in equation 3.n.…”

Section: Radiolysis Of Tcomentioning

confidence: 99%

Final Report, Research Program to Investigate the Fundamental Chemistry of Technetium

Lukens¹,

Fickes²,

Bucher³

et al. 2000

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“…The chemical reaction reducing NOg by ascorbate is also a typical hydrogen abstraction; equation (2). The rate constant of the reaction is reported to be 1 84 x 10' M"^ s"' (Forni et al 1986). …”

Section: Introductionmentioning

confidence: 99%

“…This compound occurs within the aqueous phase of the cell compartments, and hence, also within the apoplast (Castillo & Greppin, 1988;Polle, Chakrabarti & Rennenberg, 1991). Investigations done by Forni et al (1986) show that ascorbate in weakly acidic solution is able to reduce NO3, yielding nitrous acid and dehydroascorbate. Thus it seems possible that apoplastic ascorbate scavenges NO^ just before it reaches the plasma membranes.…”

Section: Introductionmentioning

confidence: 99%

Apoplastic antioxidants as decisive elimination factors within the uptake process of nitrogen dioxide into leaf tissues

et al. 1993

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SUMMARYUptake of NO^ via stomata and its elimination in the mesophyil are investigated by use of mathematical models. Systems of differential equations describe simultaneous diffusion and reaction of the chemical species taken into account. The connmon hypothesis, postulating tht disproportionation reaction of NOj being the predominant path for the transformation of NO^ into the cellular nitrate and nitrite pools, could be false because of its failure to reproduce the measured sorption characteristics. If however the reduction of the pro-oxidative NO^ by apoplastic ascorbate is taken into account the calculated uptake rates and the effects of changes in immission concentration and vegetational characteristics fit well within corresponding experimental results. The onset of acute injury in case of a fall in apoplastic ascorbate concentration below a critical level is postulated.

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Nitrogen dioxide and related free radicals: electron-transfer reactions with organic compounds in solutions containing nitrite or nitrate

Cited by 131 publications

References 10 publications

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca‐ATPase of rat skeletal muscle during aging: a peroxynitrite‐mediated process?

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca‐ATPase of rat skeletal muscle during aging: a peroxynitrite‐mediated process?

Final Report, Research Program to Investigate the Fundamental Chemistry of Technetium

Apoplastic antioxidants as decisive elimination factors within the uptake process of nitrogen dioxide into leaf tissues

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