Nitrogen donor ligands bearing N–H groups: Effect on catalytic and cytotoxic activity of molybdenum η3-allyldicarbonyl complexes

Mo(II) complexes: A new family of cytotoxic agents?

“…This geometric arrangement is equivalent to that observed in the related complex [Mo(η 3 -C 3 H 5 )(CF 3 SO 3 )(CO) 2 (2-(2′-pyridyl) benzimidazole)] [25], in which the Mo-OSO 2 CF 3 bond makes with the 2-(2′-pyridyl)benzimidazole plane an angle of 79.1°. The Mo-O bond of 2.264(2) Å in T1 is slightly longer than the corresponding one of 2.2394(15) Å in T2, which is similar to the observed in the quoted complex (2.233(5) Å).…”

“…All the complexes with X = Br were obtained directly from reaction between [MBr(η 3 -C 3 H 5 )(CO) 2 (CH 3 CN) 2 ] (M = Mo, [26]W, [27]) and the diimine ligand, which led to the substitution of the two nitrile ligands (similarly for X = Cl). Reaction of [Mo(η 3 -C 3 H 5 )Br(CO) 2 (N-N)] with Tl[CF 3 SO 3 ] in CH 3 CN resulted in loss of the halide and coordination of the triflate ion, as reported for other complexes [25]. The triflate complexes T1 and T2 were structurally characterized by single crystal X-ray diffraction (see 3.2).…”

“…On the other hand, complexes [Mo(η 3 -C 3 H 5 )X(CO) 2 (N-N)], with X = Br, CF 3 SO 3 and N-N = 2-(2′-pyridyl)benzimidazole) or 2-(2′-pyridyl)imidazole) exhibited a high activity against several cell lines [25]. In this study, we describe the noticeable antitumor activity of a family of 2,2′-bipyridyl and 1,10-phenanthroline molybdenum complexes with halide and triflate counter-anions, and perform a series of biological studies in order to provide new insights on the mechanisms of action of these compounds.…”

Highly Water‐Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes – Second Generation of Molybdenum‐Based Cytotoxic Agents

“…Our investigation follows the fundamental work of Romão et al, who established the allyl [(η 3 -C3H5)Mo(CO)2L2Br], cyclopentadienyl and indenyl molybdenum compounds [(η 5 -Cp')Mo(CO)2L2][BF4] (Cp': Cp = C5H5, Ind = C9H7), where L2 is N,N-, S,S-or P,P-chelating ligand, as new class of highly cytotoxic species against several tumor cell lines. [5] Following studies have extended the series of cytotoxic active compounds [6] and brought an early insight into mechanism of their action. [7] The cytotoxicity of the molybdenum compounds seems to correlate mainly with nature of coordinated chelating ligand while the substitution in the π-coordinated ligand play only minor role.…”

Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

“…The Schiff bases containing ONS donor atoms act as superior chelating agents for the transition and nontransition metal ions and showed remarkable biological activities [2, 3]. Coordination of these compounds with metal ions, such as copper and nickel, often enhance their activities [4].…”