Nitrogen-doped multiple graphene aerogel/gold nanostar as the electrochemical sensing platform for ultrasensitive detection of circulating free DNA in human serum

Ruiyi, Li; Liu, Ling; Hongxia, Bei; Li, Zaijun

doi:10.1016/j.bios.2015.12.092

Cited by 62 publications

(14 citation statements)

References 52 publications

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“…Several challenges have been also focused on the detection of both circulating ss/ds DNA. Ruiyi et al developed a nitrogen-doped multiple graphene aerogel/gold nanostar biosensor (N-doped MGA/GNS) able to detect dsDNA by human serum via electrochemical approach [94]. The hybrid N-doped MGA/GNS system showed an electrocatalytic activity towards Fe (CN) 6 3−/4− improved in the presence of dsDNA, which was demonstrated by amperometric detection.…”

Section: Circulant Tumor Nucleic Acids (Ctnas)mentioning

confidence: 99%

“…The hybrid N-doped MGA/GNS system showed an electrocatalytic activity towards Fe (CN) 6 3−/4− improved in the presence of dsDNA, which was demonstrated by amperometric detection. The authors ascribed this behavior to the interaction between DNA and under-coordinated Au(I) sites bonded on the N-doped MGA-5 surface [94]. Another electrochemical biosensor composed of G decorated with Au nanorods and polythionine film (G/Au NR/PT) deposited onto glassy carbon electrode (GCE) was developed by Huang et al for the detection of human papillomavirus (HPV) DNA in human serum [95].…”

Section: Circulant Tumor Nucleic Acids (Ctnas)mentioning

confidence: 99%

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Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis

et al. 2020

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Graphene-based materials are intriguing nanomaterials with applications ranging from nanotechnology-related devices to drug delivery systems and biosensing. Multifunctional graphene platforms were proposed for the detection of several typical biomarkers (i.e., circulating tumor cells, exosomes, circulating nucleic acids, etc.) in liquid biopsy, and numerous methods, including optical, electrochemical, surface-enhanced Raman scattering (SERS), etc., have been developed for their detection. Due to the massive advancements in biology, material chemistry, and analytical technology, it is necessary to review the progress in this field from both medical and chemical sides. Liquid biopsy is considered a revolutionary technique that is opening unexpected perspectives in the early diagnosis and, in therapy monitoring, severe diseases, including cancer, metabolic syndrome, autoimmune, and neurodegenerative disorders. Although nanotechnology based on graphene has been poorly applied for the rapid diagnosis of viral diseases, the extraordinary properties of graphene (i.e., high electronic conductivity, large specific area, and surface functionalization) can be also exploited for the diagnosis of emerging viral diseases, such as the coronavirus disease 2019 (COVID-19). This review aimed to provide a comprehensive and in-depth summarization of the contribution of graphene-based nanomaterials in liquid biopsy, discussing the remaining challenges and the future trend; moreover, the paper gave the first look at the potentiality of graphene in COVID-19 diagnosis.

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Section: Circulant Tumor Nucleic Acids (Ctnas)mentioning

confidence: 99%

Section: Circulant Tumor Nucleic Acids (Ctnas)mentioning

confidence: 99%

Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis

et al. 2020

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“…The heteroatom‐doping carbon aerogels with enhanced electrochemical behavior and activity are the suitable support materials for the preparation of the high‐performance electrodes for biosensors. The activated N‐doped graphene aerogel‐supported PtAu nanoalloys and Au nanostars composites were successfully applied as high‐performance biosensors for the electrochemical detection of DA and double stranded DNA, respectively . For the development of low cost and highly sensitive biosensor electrodes for the detection of breast cancer, Kazerooni and Nassernejad synthesized the N‐doped graphene aerogels grafted with the supramolecular ionic liquids by the combination of hydrothermal, freeze‐drying, and modification process.…”

Section: Aerogel‐based Sensorsmentioning

confidence: 99%

Versatile Aerogels for Sensors

Yang

Zheng

et al. 2019

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Aerogels are unique solid‐state materials composed of interconnected 3D solid networks and a large number of air‐filled pores. They extend the structural characteristics as well as physicochemical properties of nanoscale building blocks to macroscale, and integrate typical characteristics of aerogels, such as high porosity, large surface area, and low density, with specific properties of the various constituents. These features endow aerogels with high sensitivity, high selectivity, and fast response and recovery for sensing materials in sensors such as gas sensors, biosensors and strain and pressure sensors, among others. Considerable research efforts in recent years have been devoted to the development of aerogel‐based sensors and encouraging accomplishments have been achieved. Herein, groundbreaking advances in the preparation, classification, and physicochemical properties of aerogels and their sensing applications are presented. Moreover, the current challenges and some perspectives for the development of high‐performance aerogel‐based sensors are summarized.

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“…The overpotential during electrocatalytic H 2 O 2 reduction was significantly reduced, and a well-defined and enhanced H 2 O 2 reduction peak was observed around −0.2 V, demonstrating better NG electrocatalytic activity compared to undoped graphene for H 2 O 2 sensing. Ruiyi et al [6] incorporated nitrogen in multiple graphene aerogel/gold nanostars (N-doped MGA/GNS) and reported that such a sensor was more sensitive than that of all reported DNA sensors to date. Saengsookwaow et al [7] showed that, during cyclic voltammetry, a screen-printed carbon electrode (SPCE) functionalized by NG/Polyvinylpyrrolidone PVP/Gold nanoparticles (AuNPs) increased the anodic peak current by a factor of 10 compared to unmodified SCPE, due to a significant improvement in the interfacial charge transfer.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical Performance of Nitrogen-Doped Graphene Films Processed in One Step by Pulsed Laser Deposition Directly Coupled with Thermal Annealing

et al. 2019

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Graphene-based materials are widely studied to enable significant improvements in electroanalytical devices requiring new generations of robust, sensitive and low-cost electrodes. In this paper, we present a direct one-step route to synthetize a functional nitrogen-doped graphene film onto a Ni-covered silicon electrode substrate heated at high temperature, by pulsed laser deposition of carbon in the presence of a surrounding nitrogen atmosphere, with no post-deposition transfer of the film. With the ferrocene methanol system, the functionalized electrode exhibits excellent reversibility, close to the theoretical value of 59 mV, and very high sensitivity to hydrogen peroxide oxidation. Our electroanalytical results were correlated with the composition and nanoarchitecture of the N-doped graphene film containing 1.75 at % of nitrogen and identified as a few-layer defected and textured graphene film containing a balanced mixture of graphitic-N and pyrrolic-N chemical functions. The absence of nitrogen dopant in the graphene film considerably degraded some electroanalytical performances. Heat treatment extended beyond the high temperature graphene synthesis did not significantly improve any of the performances. This work contributes to a better understanding of the electrochemical mechanisms of doped graphene-based electrodes obtained by a direct and controlled synthesis process.

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Nitrogen-doped multiple graphene aerogel/gold nanostar as the electrochemical sensing platform for ultrasensitive detection of circulating free DNA in human serum

Cited by 62 publications

References 52 publications

Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis

Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis

Versatile Aerogels for Sensors

Electroanalytical Performance of Nitrogen-Doped Graphene Films Processed in One Step by Pulsed Laser Deposition Directly Coupled with Thermal Annealing

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