The use of excessive amounts of nitrogen fertilizers in crops usually results in nitrogen (N) losses, increasing environmental pollution and contributing to climate change, while also elevating crop production costs. This study aimed to determine in maize (Zea mays L.): (1) the economic optimal nitrogen rate (EONR), economic optimal yield (EOY), and N use efficiency (NUE) utilizing the current N/maize (grain) price ratio (N/MPR) for attainable yield levels; and (2) the effect of an increase in the N/MPR on the EONR, EOY, net income (NI), NUE, and the loss of N. Data from 140 maize response experiments to increasing rates of N, conducted between 2010 and 2019 across 18 states in Mexico under rainfed and irrigated conditions, were analyzed. In these experiments, the average maximum yields were 4.971 ± 2.716 Mg ha-1 under rainfed conditions and 11.776 ± 2.366 Mg ha-1 under irrigated conditions. The EONR, EOY, and NUE were determined with the current N/MPR for attainable yield levels. At these levels, both the EONR and NUE increased with higher EOY and decreased with increased yield without N treatment. An increase in N/MPR reduced EONR and its associated costs without significantly affecting EOY and NI. The reduction in EONR resulted in higher NUE and, consequently, lower N losses. By utilizing N/MRP in economic optimization, recommended N rates for maize can be reduced, leading to decreased N losses and environmental pollution.