The concentrations of nutrients (NH4 + , NO2-, NO3and PO4 3-), COD, BOD5, coliform, turbidity and eight metals (As, Cd, Ni, Hg, Cu, Pb, Zn and Cr) were investigated in surface water of the Nhue River and To Lich River, Vietnam for 7 years (2010-2017, except 2014). The results from 505 samples demonstrated that concentrations of all these contaminants showed significant spatial and temporal variations. The Nhue River water was seriously polluted by NH4 + (0.025-11.28 mg/L), PO4 3-(0.17-1.72 mg/L), BOD5 (5.8-179.6 mg/L), COD (1.4-239.8 mg/L) and coliform (1540-326470 CFU/100L); moderately polluted by As (0.2-131.15 μg/L) and Hg (0.11-4.1 μg/L); and slightly polluted by NO2-(0.003-0.33 mg/L) and Cd (2.1-18.2 μg/L). The concentrations of NH4 + , PO4 3-, COD, BOD5 and coliform exceeded the drinking water guidelines at all sites and exceeded the irrigation water standards at some locations. Regarding heavy metals, only As, Cd and Hg contents were higher than the permissible limits at some locations while others were below the guideline values. Risks of metals on human health were evaluated by using hazard index (HI) and cancer risk through ingestion and dermal contacts for adults and children. It indicated that As was the most important pollutant leading to non-carcinogenic and carcinogenic concerns. The noncarcinogenic risks of As (HI 1.83-7.4 for adults and 2.6-10.5 for children) were higher than the acceptable values of 1.0 at all sites for both adults and children, while As posed significant carcinogenic risks for adults (1x10-4-4.96x10-4) but not for children (0.27x10-4-1.6x10-4). The study indicated that metals posed hazards mainly by oral intake in drinking water pathway.