2023
DOI: 10.1038/s41598-023-45597-z
|View full text |Cite
|
Sign up to set email alerts
|

Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio

Marietta Straub,
Alexandra Auderset,
Laurence de Leval
et al.

Abstract: Studies have suggested that cancerous tissue has a lower 15N/14N ratio than benign tissue. However, human data have been inconclusive, possibly due to constraints on experimental design. Here, we used high-sensitivity nitrogen isotope methods to assess the 15N/14N ratio of human breast, lung, and kidney cancer tissue at unprecedented spatial resolution. In lung, breast, and urothelial carcinoma, 15N/14N was negatively correlated with tumor cell density. The magnitude of 15N depletion for a given tumor cell den… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 51 publications
0
0
0
Order By: Relevance