Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-lived NO That Is Trafficked by Interacting Proteins

Glutathione metabolism and Parkinson's disease

“…Although necessary for cell signaling and enzyme activity, NO and iron are toxic when free and in excess concentrations within the cell [207–209]. Within the cell, free iron can complex with intracellular NO and GSH to form dinitrosyl-dithiol-iron complexes (DNICs) [206, 210]. A recent study has demonstrated the selective relationship between GSTP1, DNIC’s and MRP1 [211].…”

Redox conversions of dinitrosyl iron complexes with natural thiol-containing ligands

“…It is exactly at that time that we came to conjecture that the distribution of spin density in low-spin (S = ½) M-DNIC with thiolcontaining ligands is described by the formula {(RS À ) 2 Fe + (NO + ) 2 }, i.e., the unpaired electron is predominantly localized on the iron atom with the electronic configuration d 7 ({Fe(NO) 2 } 7 in the Feltham-Enemark presentation [6]), and only a small part of it is localized on thiol and nitrosyl ligands [7,8]. Such a distribution of spin density was inferred from the analysis of the hyperfine structure (HFS) of the EPR signal of M-DNIC with thiol-containing ligands.…”

“…Biologically active, low-molecular or protein-bound dinitrosyl iron complexes (DNIC) with natural thiol (RS)-containing ligands, viz., glutathione, cysteine or protein residues of cysteine (the chemical formulas of their mononuclear and binuclear forms appear as {(RS) 2 Fe(NO) 2 } and {(RS) 2 Fe 2 (NO) 4 }, respectively), represent endogenous derivatives of nitric monoxide (NO) generated in living systems under the action of exogenous or endogenous NO [1,2]. Their mononuclear form (M-DNIC) is paramagnetic and characterized by an EPR signal at g aver.…”

Nitric Oxide Signaling in Biology

“…The increased production of NO in induced macrophages is essential for the control of parasitic microorganisms, intracellular bacteria, and killing of cancer cells and tumor tissues. (Forstermann and Sessa, 2012;MacMicking et al, 1997;Nathan and Hibbs, 1991;Suryo Rahmanto et al, 2012;Wei et al, 1995). NO interacts with the DNA of target cells and causes strand breaks and fragmentation.…”

“…NO signaling forms an integrated signaling web that regulates many physiological and pathophysiological processes (Erusalimsky and Moncada, 2007;Gotoh and Mori, 2006;Zweier and Talukder, 2006). The chemical interaction between NO and biological targets is an important factor in its role as signaling molecule (Erusalimsky and Moncada, 2007;Gotoh and Mori, 2006;Suryo Rahmanto et al, 2012). In humans, in order to improve our understanding and treatment of disease, it is important to understand the biological effects of NO and its cellular signaling functions.…”