“…Decompression sickness in divers is analogous to GBT in some ways because both are caused by bubble formation in tissues as a result of gas supersaturation. In humans, exercise during diving has been demonstrated to exacerbate (Van der Aue, Brinton, & Kellar, 1945), relieve (Dujić et al, 2005; Jankowski, Nishi, Eaton, & Griffin, 1997; Jankowski, Tikuisis, & Nishi, 2004), or have no effect (Jankowski et al, 2004; Radermacher et al, 1990) on symptoms of decompression sickness, depending on the type of exercise and its timing during the dive. There is also evidence from studies on animals such as rats and bullfrogs ( Rana catesbeiana , Whitaker, Blinks, Berg, Twitty, & Harris, 1945), crustaceans ( Pachygrapsus crassipes , Pagurus hirsutiusculus , and Pagurus samuelis , McDonough & Hemmingsen, 1984a, 1984b), channel catfish ( Ictalurus punctatus ), and woolly sculpin ( Clinocottus analis , McDonough & Hemmingsen, 1985) that locomotion promotes bubble formation in tissues during decompression and that bubbles form preferentially in limbs that move during decompression (McDonough & Hemmingsen, 1984a, 1984b).…”