Nitrogen-phosphorous co-doped carbonized chitosan nanoparticles for chemotherapy and ROS-mediated immunotherapy of intracellular Staphylococcus aureus infection

Dai, Xiaomei; Liu, Xiaojun; Li, Yu; Xu, Qingqing; Yang, Lele; Gao, Feng

doi:10.1016/j.carbpol.2023.121013

Cited by 6 publications

(3 citation statements)

References 61 publications

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“…As shown in Figure S5, the XPS spectra of CTS, CTS-APs, and CTS-APs@DMY consistently showed three typical peaks of C 1s (285.08 eV), N 1s (400.22 eV), and O 1s (531.06 eV). High-resolution XPS spectrum of O 1s in CTS (Figure S6a) displayed three characteristics peaks at 533.16, 531.97, and 530.23 eV, representing CO, C–O, and O–H, respectively . Furthermore, the high-resolution XPS spectrum of N 1s in CTS (Figure S6b) was deconvoluted into two peaks, which are related to C–N (401.78 eV) and N–H (399.48 eV) .…”

Section: Resultsmentioning

confidence: 99%

“…High-resolution XPS spectrum of O 1s in CTS (Figure S6a) displayed three characteristics peaks at 533.16, 531.97, and 530.23 eV, representing C�O, C−O, and O−H, respectively. 42 Furthermore, the high-resolution XPS spectrum of N 1s in CTS (Figure S6b) was deconvoluted into two peaks, which are related to C−N (401.78 eV) and N−H (399.48 eV). 43 After constructing CTS-APs@DMY, the deconvolution peaks of O 1s and N 1s (Figure 2f,g) were shifted to higher binding energies, indicating that they act as hydrogen bond donors sharing outer orbital electrons with the hydrogen atom.…”

Section: Structural Characterizationmentioning

confidence: 99%

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Self-Assembled Biofunctionalized Chitosan-Derived Nanocomposite for Long-Lasting Antibacterial Packaging at Room Temperature

Yang,

Chen,

Chen

et al. 2023

ACS Sustainable Chem. Eng.

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The development of biobased antibacterial nanomaterials for normal-temperature food preservation is important to prevent foodborne pathogenic infections and achieve low-carbon life. Herein, we developed a biodegradable self-assembling polymer-based nanocomposite with efficient antibacterial activity through the copolymerization of chitosan units with Astragalus polysaccharides and functional dihydromyricetin. The as-prepared irregular spherical-type nanocomposite exhibited multidimensional antibacterial action such as cell membrane devastation, cellular leakages, and respiratory disturbance (ATP pathway), thereby achieving an efficient inhibition in vitro against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). After the natural deposition of the designed nanocomposite onto a commercial fiber paper (FP), the resulting modified FP was found to possess remarkable pathogen eradication, enhanced UV shielding, and improved water vapor barrier properties. As a proof-of-concept demonstration, the shelf life of salt-baked chicken (processed food) packaged in the modified FP was extended to 5 days in a room-temperature environment. Therefore, the simple design and validation of polymerbased nanocomposite in this work will provide a good reference for room-temperature food preservation technology.

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Section: Resultsmentioning

confidence: 99%

Section: Structural Characterizationmentioning

confidence: 99%

Self-Assembled Biofunctionalized Chitosan-Derived Nanocomposite for Long-Lasting Antibacterial Packaging at Room Temperature

Yang,

Chen,

Chen

et al. 2023

ACS Sustainable Chem. Eng.

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“…The results indicate that NPCNs can be used as a fluorescent probe for bacteria imaging and kill extracellular and intracellular bacteria with low cytotoxicity. 62 Aida Haji Hossein Tabrizi prepared chitosan nanoparticles with an average diameter of 246 nm. Using the ion gelation method and isolated 50 clinical uropathogenic Escherichia coli (UPEC) resistant to ciprofloxacin.…”

Section: Antibacterial Effects Of Chitosan and Chitosan Nanoparticlesmentioning

confidence: 99%

Research and Application of Chitosan Nanoparticles in Orthopedic Infections

Shi,

Zhou

et al. 2024

IJN

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Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection

Wang,

Pan,

et al. 2024

Advanced Materials

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Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail and lead to persistent and recurrent infections. The main culprits are 1) persistent bacteria reviving, colonizing, and rejuvenating biofilms, and 2) secondary pathogen exposure, particularly in individuals with chronic diseases. Addressing how to inhibit persistent bacteria revival and prevent reinfection simultaneously is still a major challenge. Herein, an oligo‐ethylene glycol‐modified lipophilic cationic photosensitizer (PS), TBTCP‐PEG7, is developed. It effectively eradicates Methicillin‐Resistant Staphylococcus aureus (MRSA) under light irradiation. Furthermore, TBTCP‐PEG7‐mediated photodynamic therapy (PDT) not only conquers stubborn biofilm infections by downregulating the two‐component system (TCS), quorum sensing (QS), and virulence factors, thereby reducing intercellular communication, inhibiting persistent bacterial regrowth and biofilm remodeling but also prevents reinfection by upregulating heat shock protein‐related genes to induce immunogenetic cell death (ICD) and establish immune memory. In vivo, TBTCP‐PEG7 efficiently eradicates MRSA biofilm adhered to medical catheters, stimulates angiogenesis, reduces inflammatory factor expression, and accelerates wound healing. Furthermore, ICD promotes short‐term immune and long‐term immunological memory for coping with secondary infections. This two‐pronged strategy not only effectively overcomes stubborn, persistent and recurrent biofilm infection, but also provides theoretical guidance for designing the next generation of antibacterial materials.

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Nitrogen-phosphorous co-doped carbonized chitosan nanoparticles for chemotherapy and ROS-mediated immunotherapy of intracellular Staphylococcus aureus infection

Cited by 6 publications

References 61 publications

Self-Assembled Biofunctionalized Chitosan-Derived Nanocomposite for Long-Lasting Antibacterial Packaging at Room Temperature

Self-Assembled Biofunctionalized Chitosan-Derived Nanocomposite for Long-Lasting Antibacterial Packaging at Room Temperature

Research and Application of Chitosan Nanoparticles in Orthopedic Infections

Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection

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