Nitroprusside therapy in acute and chronic coronary heart disease

Miller, Richard R.; Awan, Najam A.; Mason, Dean T.

doi:10.1016/0002-9343(78)90706-4

Cited by 17 publications

(3 citation statements)

References 24 publications

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“…The results we obtained with the administration of NP alone are consistent with those of previous reports on the use of this agent in congestive heart failure (Chatterjee and Parmley, 1977;Guiha et al, 1974;Miller et al, 1975Miller et al, , 1978.…”

Section: Discussionsupporting

confidence: 92%

“…These findings, therefore, are consistent with those of previous works concerning Ib effects in patients with idiopathic cardiomyopathy , 1983. Regarding the effect on PAP, there is however, a partial disagreement with what we observed in previous studies showing a 25-30% reduction of this parameter after Ib administration , 1983Guiha et al, 1974;Miller et al, 1976Miller et al, , 1978Stefoni et al, 198 I).…”

Section: Discussionsupporting

confidence: 90%

“…tial disagreement with what we observed in previous studies showing a 25-30% reduction of this parameter after Ib administration , 1983Guiha et al, 1974;Miller et al, 1976Miller et al, , 1978Stefoni et al, 198 I). It must be kept in mind, however, that the administration of a strong vasodilator agent such as NP, capable of inducing almost maximal pulmonary dilating effects, might have inhibited Ib from increasing its action.…”

Section: Discussioncontrasting

confidence: 86%

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Hemodynamic advantage of combined administration of oral ibopamine and nitroprusside in patients with ischemic and idiopathic congestive cardiomyopathy

Dei

Fappani

Riva

et al. 1985

Clinical Cardiology

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Summary: The hemodynamic efffects of combined administration of ibopamine (Ib) (150 mg orally) with nitroprusside (NP) (50-150 pg/min intravenously) were compared with those of NP alone in 17 patients with severe congestive heart failure due to coronary artery disease (7 patients) or idiopathic cardiomyopathy (10 patients). Hernodynamic measurements were obtained using a Swan-Ganz thermodilution catheter and a bedside thermodilution cardiac output computer. Nitroprusside alone produced a significant decrease (-12.4%) in mean arterial pressure, mean pulmonary arterial pressure (-28.3%), and systemic vascular resistance (-22.6%), and a significant increase in stroke volume index (23.1 %). The administration of combined NP and Ib produced a further significant increase of stroke volume index (20.1 %) with a concomitant and significant reduction of systemic vascular resistance (-19.4%); heart rate, mean systemic and pulmonary arterial pressures did not change significantly from the values observed with NP alone. Moreover, stroke work index, although not significantly modified with the vasodilator alone, was significantly increased over control values with NP+Ib association. Although NP alone induced similar effects in both the ischemic and idiopathic cardiomyopathies, the association of Ib gave a more favorable, though not significant, hemodynamic response in the subjects with primitive cardiomyopathy than in the ischemic ones. Thus, the association of Ib to NP therapy, in patients with congestive heart failure, further increases stroke volume index and stroke work index with a concomitant reduction of systemic vascular resistance, without any significant change in mean systemic and pulmonary arterial pressures, or hem rate. These results point out the possibility of associating Ib with other orally active vasodilators in the chronic treatment of congestive heart failure.

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Section: Discussionsupporting

confidence: 92%