Nitropyrazoles 23. Synthesis of substituted N-amino-3-nitro-5-R-pyrazoles

Abstract

The study is devoted to nucleophilic substitution of nitro groups in 1 amino 3,5 dinitro pyrazole (1) and its amino group derived analogs. Compound 1 upon treatment with S nucleo philes undergoes regioselective substitution of the nitro group at position 5. Azomethine 5 obtained by the condensation of 1 with benzaldehyde gives the nucleophilic substitution reac tion with S , O and N nucleophiles also with involvement of the nitro group at position 5. The synthesized 5 R substituted azomethines 7-9 upon treatment with hydrazine hydrate form N amino 5 R 3 nitropyrazoles and benzaldazine.