Nitrosilo complexos de rutênio(II) como captores de radicais de interesse biológico

Metzker, Gustavo

doi:10.11606/d.75.2009.tde-26082009-105920

Cited by 1 publication

(2 citation statements)

References 51 publications

(92 reference statements)

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“…The nitrosyl complexes of the class trans-[Ru II (NH 3 ) 4 (L)(NO)] 3+ are considered important molecules because of their low toxicity, good solubility in water, and ability to modulate the release of NO as a function of the trans effect played by the choice of ligand L, along with the fact that the reductive potential of NO + is accessible to many reducing agents found in biological processes 5 , 6 . The nature of the ligand L is exactly what controls the strength of the Ru–NO bond so that the higher the binding property of the receptor, the weaker is the strength of the NO bond 9 .…”

Section: Discussionmentioning

confidence: 99%

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Vascular Response of Ruthenium Tetraamines in Aortic Ring from Normotensive Rats

Conceição-Vertamatti¹,

Ramos²,

Calandreli³

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundRuthenium (Ru) tetraamines are being increasingly used as nitric oxide (NO) carriers. In this context, pharmacological studies have become highly relevant to better understand the mechanism of action involved.ObjectiveTo evaluate the vascular response of the tetraamines trans-[RuII(NH3)4(Py)(NO)]3+, trans-[RuII(Cl)(NO) (cyclan)](PF6)2, and trans-[RuII(NH3)4(4-acPy)(NO)]3+.MethodsAortic rings were contracted with noradrenaline (10−6 M). After voltage stabilization, a single concentration (10−6 M) of the compounds was added to the assay medium. The responses were recorded during 120 min. Vascular integrity was assessed functionally using acetylcholine at 10−6 M and sodium nitroprusside at 10−6 M as well as by histological examination.ResultsHistological analysis confirmed the presence or absence of endothelial cells in those tissues. All tetraamine complexes altered the contractile response induced by norepinephrine, resulting in increased tone followed by relaxation. In rings with endothelium, the inhibition of endothelial NO caused a reduction of the contractile effect caused by pyridine NO. No significant responses were observed in rings with endothelium after treatment with cyclan NO. In contrast, in rings without endothelium, the inhibition of guanylate cyclase significantly reduced the contractile response caused by the pyridine NO and cyclan NO complexes, and both complexes caused a relaxing effect.ConclusionThe results indicate that the vascular effect of the evaluated complexes involved a decrease in the vascular tone induced by norepinephrine (10−6 M) at the end of the incubation period in aortic rings with and without endothelium, indicating the slow release of NO from these complexes and suggesting that the ligands promoted chemical stability to the molecule. Moreover, we demonstrated that the association of Ru with NO is more stable when the ligands pyridine and cyclan are used in the formulation of the compound.

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Section: Discussionmentioning

confidence: 99%

“…Metal complexes of Ru (II) have become the focus of research because of its remarkable ability to bind to various compounds. In addition, it is the element that best forms nitrosyl complexes 5 , 6 .…”

Section: Introductionmentioning

confidence: 99%