Nitrous oxide: A psychotogenic agent

Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature

“…57 Others have reported that N 2 O leads to psychotic symptoms via cerebral anoxia, methemoglobinemia, low arterial pO 2 , and acidosis. 58 There are several problems and challenges related to the detection and evaluation of sequelae related to N 2 O abuse which represent limitations for this review. As with all substances of abuse, it can be difficult to quantify truly and accurately the degree of N 2 O abuse.…”

Nitrous Oxide Inhalation Among Adolescents: Prevalence, Correlates, and Co-Occurrence with Volatile Solvent Inhalation

“…NO abuse has been observed in conjunction with cognitive problems including memory (Duarte et al 2008) and attentional (Estrin et al 1988) impairments. Serious psychological consequences have been associated with NO intoxication, including depression (Brouette & Anton 2001), other mood disorders (Grigg 1988), and psychosis (Brodsky & Zuniga 1975; Sethi et al 2006). …”

Rehabilitation essential in the recovery of multifactorial subacute combined degeneration

“…A dearth of literature exists on acute psychosis in the context of both N 2 O exposure or abuse and B12 deficiency. Patients with N 2 O exposure or usage and B12 deficiency both present with similar symptoms of memory loss, psychosis, hallucinations [7,8]. The combination of the acute on chronic B12 deficiency and the N 2 O abuse of our patient led to a compounded clinical picture including severe hallucinations and paranoia, requiring medication and psychiatric monitoring and treatment during his hospitalization.…”