Nitrous Oxide Effects on Isolated Myocardium

Lawson, Dan; Frazer, Martha J.; Lynch, Carl

doi:10.1097/00000542-199011000-00022

Cited by 13 publications

(5 citation statements)

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“…A few in vitro investigations regarding the effects of N 2 O on myocardial muscle have indicated that N 2 O depressed contractility similar to, or more than that in controls. [25][26][27] Regarding sympathetic effects, N 2 O, but not Xe, has been reported to augment its outflow. The sympathetic activation by N 2 O has been shown by elevated plasma catecholamine concentrations 23 and by microneurography.…”

Section: 516mentioning

confidence: 99%

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Nakayama¹,

Takahashi

Okubo

et al. 2002

Can J Anesth/J Can Anesth

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Section: 516mentioning

confidence: 99%

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Nakayama¹,

Takahashi

Okubo

et al. 2002

Can J Anesth/J Can Anesth

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“…In cardiac patients after cardiopulmonary bypass, nitrous oxide unmasked myocardial depression, leading to decrease in mean arterial pressure, cardiac index, heart rate, and stroke volume [21]. The decrease in blood pressure in this study may have been the result of potentiation of b-2 mediated vasodilatation of isoflurane, and the additive myocardial depressant effects of isoflurane and nitrous oxide [22][23][24]. Previous studies have reported similar results, with a decreased mean arterial pressure using Doppler echocardiography during nitrous oxide anaesthesia with a background of halothane or isoflurane [25].…”

Section: Discussionmentioning

confidence: 72%

Haemodynamic Changes During Craniotomy Monitored By A Bioimpedance Plethysmographic Noninvasive Cardiac Output Monitor

Ali

Rao

Jaganath

2009

J Clin Monit Comput

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“…[28][29][30] Reducing the concentration of the volatile agent by adding a less potent myocardial depressant drug (nitrous oxide) 26 should reduce depression of cardiac function, but we found that this occurred only with isoflurane. Lawson, Frazer and Lynch 27 found that nitrous oxide, in common with halothane, reduced Ca 2; release from the sarcoplasmic reticulum of the myocyte but that the effects of isoflurane were of a different character. However, they found that the addition of nitrous oxide to either halothane or isoflurane caused simple additive depression of myocardial function with both agents.…”

Section: Discussionmentioning

confidence: 99%

“…Isoflurane, halothane and nitrous oxide exhibit dose-dependent myocardial depression by interacting with Ca 2; effects in the myocyte, [25][26][27] although the exact mechanisms may differ between halothane and isoflurane. [28][29][30] Reducing the concentration of the volatile agent by adding a less potent myocardial depressant drug (nitrous oxide) 26 should reduce depression of cardiac function, but we found that this occurred only with isoflurane.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular effects of 50% nitrous oxide in older adult patients anaesthetized with isoflurane or halothane

McKinney¹,

Fee²

1998

British Journal of Anaesthesia

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We have studied the cardiovascular effects of equipotent concentrations of halothane or isoflurane, with or without 50% nitrous oxide in oxygen, in 80 patients, aged 60 yr or more, during 20 min of stable equipotent anaesthesia. Non-invasive measurement techniques were used, with suprasternal Doppler ultrasonography for estimating cardiac output. Both isoflurane and halothane reduced heart rate and systemic arterial pressure. With isoflurane, mean rate decreased from 72 (SD 9.7) to 67 (10.4) beat min-1 and with halothane from 76 (10.1) to 65 (9.1) beat min-1 (P < 0.05). Mean diastolic arterial pressure decreased from 81 (11.3) to 58 (17.0) mm Hg with isoflurane and from 86 (14.7) to 70 (13.3) mm Hg with halothane (P < 0.05). Cardiac index decreased from 3.1 (1.03) to 2.7 (0.71) litre min-1 m-2 with isoflurane and from 3.1 (0.98) to 2.5 (0.57) litre min-1 m-2 with halothane (P < 0.05). Systemic vascular resistance decreased significantly in all groups except those receiving halothane with nitrous oxide. Nitrous oxide resulted in significantly less depression of cardiac index when given with isoflurane than when given with halothane. The mean percentage change in cardiac index during isoflurane anaesthesia without nitrous oxide was 16.7%; with nitrous oxide there was a 0.5% increase. Halothane, in combination with nitrous oxide, resulted in greater depression of cardiac index than isoflurane with nitrous oxide. The mean percentage change with halothane was 20.4% (22.2%); with isoflurane there was a 0.5% (27.1%) increase (P < 0.05). Hypotension was more pronounced in patients anaesthetized with isoflurane (n = 40) than those anaesthetized with halothane (n = 40), irrespective of the presence of nitrous oxide. The mean percentage decrease with isoflurane was 29.7% (21.10%) compared with 16.8% (16.78%) with halothane (P < 0.05).

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Nitrous Oxide Effects on Isolated Myocardium

Cited by 13 publications

References 0 publications

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Haemodynamic Changes During Craniotomy Monitored By A Bioimpedance Plethysmographic Noninvasive Cardiac Output Monitor

Cardiovascular effects of 50% nitrous oxide in older adult patients anaesthetized with isoflurane or halothane

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