Nitrous oxide elevates local anesthetic seizure threshold

Jong, Rudolph H. de; Heavner, James E.; Oliveira, Luiz Fernando de

doi:10.1016/0014-4886(72)90127-6

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…In one patient with refractory convulsions, 60% N 2 0 alone slowed but did not eliminate tonic-clonic or EEG seizure activity (85). In animals, N,O was found to elevate the local anesthetic seizure threshold (97) and to reduce the frequency of EEG spiking activity during enflurane anesthesia (98). N 2 0 remains the oldest and most widely used anesthetic in clinical practice.…”

Section: Nitrous Oxidementioning

confidence: 99%

Pro-and Anticonvulsant Effects of Anesthetics (Part I)

Modica

Tempelhoff

White

1990

Anesthesia & Analgesia

148

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Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual patient's responses to anesthetic and analgesic drugs. In addition, variations in the responsiveness of inhibitory and excitatory neurons to the central depressant effects of these drugs could also explain these apparently conflicting data. Depending on the brain concentration, centrally active drugs may produce differing effects on the CNS inhibitory and excitatory neurotransmitter systems. The availability of increasingly powerful magnetic resonance imaging techniques to provide noninvasive information about tissue chemistry (e.g., neurotransmitters and citric acid cycle metabolites) and positron emission tomography to noninvasively evaluate CNS drug-receptor interactions should lead to a more in-depth understanding of the in vivo effects of anesthetics and analgesics on the CNS. In the second part of this review article, we discuss the pro- and anticonvulsant effects of the sedative-hypnotics, local anesthetics, and other anesthetic adjuvant drugs.

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Section: Nitrous Oxidementioning

confidence: 99%

Pro-and Anticonvulsant Effects of Anesthetics (Part I)

Modica

Tempelhoff

White

1990

Anesthesia & Analgesia

148

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“…In contrast to our assumption, previous investigators reported that magnesium sulfate did not suppress lidocaine-induced seizures in anesthetized rats. 4,5 Based on previous reports that nitrous oxide, 6,7 volatile 8 or intravenous 9,10 anesthetics affected the threshold of local anesthetic-induced seizures, we postulated that the suppressive effect of magnesium sulfate on the local anesthetic-induced seizures might be different if the animal was not anesthetized. Since bupivacaine is a commonly used local anesthetic in current obstetric practice, we chose this drug to test our hypothesis.…”

Section: Introductionmentioning

confidence: 99%