1982
DOI: 10.1213/00000539-198202000-00001
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Nitrous Oxide Inactivates Methionine Synthetase in Human Liver

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Cited by 76 publications
(29 citation statements)
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“…Side effects include an increased risk of nausea and vomiting (157,158). Other reported adverse effects of nitrous oxide anesthesia include impairment of cerebral blood flow-activity coupling (159), and inactivation of methionine synthase (160,161).…”
Section: Nitrous Oxide Anesthesiamentioning
confidence: 99%
“…Side effects include an increased risk of nausea and vomiting (157,158). Other reported adverse effects of nitrous oxide anesthesia include impairment of cerebral blood flow-activity coupling (159), and inactivation of methionine synthase (160,161).…”
Section: Nitrous Oxide Anesthesiamentioning
confidence: 99%
“…Nitrous oxide oxidizes vitamin B12 and thus decreases DNA production by the inactivation of methionine synthetase. 16 The effects of this are dosedependent megaloblastic changes seen in the bone marrow which have been demonstrated in patients exposed to 50% nitrous oxide for periods as short as five hours during cardiac bypass surgery. 3 Similar bone marrow changes have been reported in dentists who experienced chronic occupational exposure to nitrous oxide in sub-anaesthetic concentrations of 1800 ppm.…”
Section: Discussionmentioning
confidence: 99%
“…This result was not appreciated in the medical community where it was only recognized in 1978 [63]. In 1982 was it demonstrated in patients' liver biopsies after exposure to 50-70 % N 2 O for 1.25-2.75 hours, that there was a decrease in methionine synthase [64].…”
Section: Inactivation Of Vitamin B12mentioning
confidence: 99%
“…Clinical symptoms include sensory neuropathy, myelopathy, and encephalopathy; they can occur within days or weeks after exposure to N 2 O anesthesia in people with subclinical vitamin B12 deficiency. In humans, the mean half-time for hepatic methionine synthase inactivation by 1 atmosphere N 2 O is approximately 1 hour (or 0.5 atmospheres for 2 hours), with less than 20 % residual activity after 2 atmosphere-hours of exposure [78]. However, others found 50 % reduction after exposure for 40 minutes to 50 % N 2 O [79].…”
Section: Inactivation Of Vitamin B12mentioning
confidence: 99%